2. Gene
  3. TRPM8 - transient receptor potential cation channel subfamily M member 8 Gene

TRPM8 - transient receptor potential cation channel subfamily M member 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TRPP8; LTRPC6; trp-p8; LTrpC-6

Gene ID: 79054 | Gene type: protein coding

About TRPM8

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,917,373-234,019,522 (from NCBI)

This gene has 14 transcripts (splice variants), 157 orthologues and 7 paralogues. Restricted expression toward prostate (RPKM 48.0).

Summary

Predicted to enable ligand-gated Calcium Channel activity. Predicted to be involved in calcium ion transmembrane transport and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including cellular calcium ion homeostasis; response to cold; and thermoception. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TRPM8 Products(25)

mRNA Protein Name
NM_001397606.1 NP_001384535.1 transient receptor potential cation channel subfamily M member 8 isoform 2
NM_001397607.1 NP_001384536.1 transient receptor potential cation channel subfamily M member 8 isoform 3
NM_001397608.1 NP_001384537.1 transient receptor potential cation channel subfamily M member 8 isoform 4
NM_001397609.1 NP_001384538.1 transient receptor potential cation channel subfamily M member 8 isoform 5
NM_001397610.1 NP_001384539.1 transient receptor potential cation channel subfamily M member 8 isoform 5
NM_001397611.1 NP_001384540.1 transient receptor potential cation channel subfamily M member 8 isoform 5
NM_001397612.1 NP_001384541.1 transient receptor potential cation channel subfamily M member 8 isoform 6
NM_001397613.1 NP_001384542.1 transient receptor potential cation channel subfamily M member 8 isoform 6
NM_001397614.1 NP_001384543.1 transient receptor potential cation channel subfamily M member 8 isoform 8
NM_001397615.1 NP_001384544.1 transient receptor potential cation channel subfamily M member 8 isoform 8
NM_001397617.1 NP_001384546.1 transient receptor potential cation channel subfamily M member 8 isoform 10
NM_001397619.1 NP_001384548.1 transient receptor potential cation channel subfamily M member 8 isoform 9
NM_001397620.1 NP_001384549.1 transient receptor potential cation channel subfamily M member 8 isoform 11
NM_001397621.1 NP_001384550.1 transient receptor potential cation channel subfamily M member 8 isoform 11
NM_001397622.1 NP_001384551.1 transient receptor potential cation channel subfamily M member 8 isoform 11
NM_001397623.1 NP_001384552.1 transient receptor potential cation channel subfamily M member 8 isoform 12
NM_001397624.1 NP_001384553.1 transient receptor potential cation channel subfamily M member 8 isoform 13
NM_001397625.1 NP_001384554.1 transient receptor potential cation channel subfamily M member 8 isoform 14
NM_001397626.1 NP_001384555.1 transient receptor potential cation channel subfamily M member 8 isoform 15
NM_001397627.1 NP_001384556.1 transient receptor potential cation channel subfamily M member 8 isoform 16
NM_001397628.1 NP_001384557.1 transient receptor potential cation channel subfamily M member 8 isoform 17
NM_001397629.1 NP_001384558.1 transient receptor potential cation channel subfamily M member 8 isoform 17
NM_001397630.1 NP_001384559.1 transient receptor potential cation channel subfamily M member 8 isoform 17
NM_001397635.1 NP_001384564.1 transient receptor potential cation channel subfamily M member 8 isoform 7
NM_024080.5 NP_076985.4 transient receptor potential cation channel subfamily M member 8 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25559186 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
25559186 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPM8 Protein Structure

Ion_trans

Ion_trans: Ion transport protein (772 - 978)

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  • 1104 a.a.
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily M member 8

TRPM8 cationic channel

Related Diseases

Diseases Alias
Migraine Without Aura

Common Migraine

Migraine With Or Without Aura, Susceptibility To

Migraine Without Aura, Susceptibility To

Acute Migraine Without Aura
Photokeratitis
Dentin Sensitivity

Sensitive Dentin
Microcephalic Osteodysplastic Primordial Dwarfism, Type I

Taybi-Linder Syndrome

Brachymelic Primordial Dwarfism

Cephaloskeletal Dysplasia

Low-Birth-Weight Dwarfism With Skeletal Dysplasia

Microcephalic Osteodysplastic Primordial Dwarfism Type I

Osteodysplastic Primordial Dwarfism Type I

Primordial Microcephalic Dwarfism, Crachami Type

Osteodysplastic Primordial Dwarfism, Type 1

MOPD1

Mopd I

Mopd

Osteodysplastic Primordial Dwarfism, Type I

Tals

Microcephalic Osteodysplastic Primordial Dwarfism Type 1

Mopd 1

Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3

Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii

Mopd Types I And Iii

Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type

Primordial Microcephalic Dwarfism Crachami Type

Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1
Diabetic Neuropathy

Diabetic Neuropathies
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Lichen Sclerosus Et Atrophicus

Lichen Sclerosus

LSA

Lichen Sclerosis

Lichen Sclerosis Et Atrophicus

Ls Et A - [Lichen Sclerosus Et Atrophicus]

Lichen Albus
Familial Episodic Pain Syndrome

Feps
Lymph Node Carcinoma

Lymph Node Cancer

Lymph Node Neoplasm

Neoplasm Of Lymph Node
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome

Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques

Palmoplantar And Periorificial Keratoderma

Olms
Atrophic Rhinitis

Rhinitis, Atrophic

Ozena

Rhinitis Sicca

Dry Rhinitis

Ozaena
Somatoform Disorder

Physiological Malfunction Arising From Mental Factor

Psychosomatic Disorder

Psychophysiologic Disorders
Trigeminal Nerve Disease

Trigeminal Nerve Diseases

Disorders Of 5th Cranial Nerve

Disorders Of The Fifth Cranial Nerve
Lacrimal Apparatus Disease

Lacrimal Apparatus Diseases
Pain Agnosia

Analgesia
Paine Syndrome

Pain Disorder

Pain

Microcephaly With Spastic Diplegia

Pain Syndrome
Agnosia

Dyspraxia

Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual

Apraxias

Alexia
Dry Eye Syndrome

Dry Eye Syndromes

Dry Eye Disease

Tear Film Insufficiency

Xerophthalmia
Ocular Hyperemia

Hyperemia Eye

Hyperemia Of Conjunctiva
Complex Regional Pain Syndrome

Complex Regional Pain Syndromes

Reflex Sympathetic Dystrophy

Crps
Trigeminal Neuralgia

Tic Douloureux

Trifacial Neuralgia

Trifocal Neuralgia

Neuralgia Of The Fifth Cranial Nerve

Neuralgia Of 5th Cranial Nerve

Infraorbital Neuralgia
Interstitial Cystitis

Bladder Pain Syndrome

Painful Bladder Syndrome

Ulcerative Cystitis

Ic/Bps

Ic/Pbs

Interstitial Cystitis/Bladder Pain Syndrome

Interstitial Cystitis/Painful Bladder Syndrome

Cystitis, Interstitial

Chronic Interstitial Cystitis

Pelvic Congestion Syndrome

Trigonitis
Erythromelalgia

Primary Erythromelalgia

Erythermalgia

Primary Erythermalgia

Mitchell Disease

Familial Erythromelalgia
Paroxysmal Extreme Pain Disorder

PEPD

Familial Rectal Pain

Pexpd

Submandibular, Ocular, And Rectal Pain With Flushing

Pain, Submandibular, Ocular, And Rectal, With Flushing

Rectal Pain, Familial

Submandibular, Ocular And Rectal Pain With Flushing

Familial Rectal Syndrome

Frp

Pain Disorder, Paroxysmal, Extreme
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Migraine With Aura

Classic Migraine

Migraine With Typical Aura

Migraine Accompagnée

Complicated Migraine

Classical Migraine

Acute Migraine With Aura
Lennox-Gastaut Syndrome

Lennox Syndrome

Encephalopathy Of Childhood

Epileptic Encephalopathy Lennox-Gastaut Type

Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

Lgs
Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-75161 (-)-Menthol Activator 99.79% Unkown
HY-B0985 Phenazopyridine hydrochloride Antagonist 99.84% Unkown
HY-B0985A Phenazopyridine Antagonist 99.93% Unkown
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-108449 Acoltremon Agonist 99.90% Phase 3
HY-112703 AMG 333 Antagonist 99.82% Phase 1
HY-16162A D-3263 hydrochloride Agonist 98.03% Phase 1
HY-115506 PF-05105679 Antagonist 99.84% Phase 1
HY-16162 D-3263 Agonist / Phase 1
Pre-clinical Phase
Bioactive Molecules (28)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101507 Pico145 Inhibitor 99.40% Unkown
HY-11062 Icilin Agonist 99.26% Unkown
HY-19960 BCTC 98.03% Unkown
HY-100345 AMTB hydrochloride Inhibitor 99.18% Unkown
HY-112430 TRPM8 antagonist 2 Antagonist 98.01% Unkown
HY-19976 RN-1747 Agonist 99.25% Unkown
HY-18662 RQ-00203078 Antagonist 99.84% Unkown
HY-N8264 Moringin Agonist 99.95% Unkown
HY-N1500 Pulegone Activator 98.80% Unkown
HY-110181 M8-B Antagonist 99.89% Unkown
HY-104059 AMG2850 Antagonist 99.89% Unkown
HY-144372 TRPV1 antagonist 3 Antagonist 99.30% Unkown
HY-145124 TRPM8 antagonist 3 Antagonist 99.51% Unkown
HY-N7117 1,4-Cineole Activator ≥95.0% Unkown
HY-109087 Elismetrep Inhibitor 99.42% Unkown
HY-110199 TC-I 2014 Antagonist ≥99.0% Unkown
HY-130074 FEMA 4809 Agonist 99.25% Unkown
HY-W014325 TRPM8 agonist WS-3 Agonist 99.35% Unkown
HY-160900 RN-1665 Antagonist 99.93% Unkown
HY-N7536 Voacangine 98.78% Unkown
HY-104061 AMG8788 Antagonist / Unkown
HY-104062 AMG9678 Antagonist / Unkown
HY-108461 TRPM8-IN-1 Inhibitor / Unkown
HY-15056 AMG 9090 Agonist / Unkown
HY-RS15118 TRPM8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-126593 Cryosim-3 / Unkown
HY-N5142S1 α-Terpineol-d6 Inhibitor / Unkown
HY-N9484S Menthofuran-13C2 / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TRPM8 MGD MGI:2181435
Felis catus TRPM8 VGNC VGNC:82512
Bos taurus TRPM8 VGNC VGNC:36394
Macaca mulatta TRPM8 VGNC VGNC:99415
Canis familiaris TRPM8 VGNC VGNC:47879
Rattus norvegicus TRPM8 RGD RGD:620762