FSD1 - fibronectin type III and SPRY domain containing 1 Gene

Homo sapiens

Also known as MIR1; GLFND

Gene ID: 79187 | Gene type: protein coding

About FSD1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,304,598-4,323,836 (from NCBI)

This gene has 10 transcripts (splice variants), 197 orthologues and 3 paralogues. Biased expression in brain (RPKM 10.1), testis (RPKM 4.8) and 2 other tissues.

Summary

This gene encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain. The encoded protein associates with a subset of microtubules and may be involved in the stability and organization of microtubules during cytokinesis. [provided by RefSeq, Apr 2009]

FSD1 Products(2)

mRNA	Protein	Name
NM_001330429.2	NP_001317358.1	fibronectin type III and SPRY domain-containing protein 1 isoform 2
NM_024333.3	NP_077309.1	fibronectin type III and SPRY domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	12154070	GOA
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	12154070	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic microtubule organization	IMP IMP: Inferred from mutant phenotype	12154070	GOA
involved in regulation of cell division	IDA IDA: Inferred from direct assay	12445389	GOA
involved in regulation of cytokinesis	IDA IDA: Inferred from direct assay	12445389	GOA
involved in regulation of mitotic spindle organization	IDA IDA: Inferred from direct assay	12154070	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IMP IMP: Inferred from mutant phenotype	12154070	GOA
located in microtubule	IMP IMP: Inferred from mutant phenotype	12154070	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fibronectin type III and SPRY domain-containing protein 1

MID1-related protein 1

Related Diseases

Diseases

Alias

Mitochondrial Dna Depletion Syndrome 12a

Spastic Paraplegia 16, X-Linked

SPG16	Hereditary Spastic Paraplegia 16
X-Linked Spastic Paraplegia Type 16	Spastic Paraplegia 16, X-Linked, Complicated
X-Linked Spastic Paraplegia 16	Spastic Paraplegia 16
Spastic Paraplegia-16, X-Linked, Complicated

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05121	FSD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FSD1	VGNC	VGNC:62375
Rattus norvegicus	FSD1	RGD	RGD:1583850
Canis familiaris	FSD1	VGNC	VGNC:40993
Bos taurus	FSD1	VGNC	VGNC:29129
Mus musculus	FSD1	MGD	MGI:1934858
Macaca mulatta	FSD1	VGNC	VGNC:72718

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