2. Gene
  3. IRX3 - iroquois homeobox 3 Gene

IRX3 - iroquois homeobox 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IRX-1; IRXB1

Gene ID: 79191 | Gene type: protein coding

About IRX3

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:54,283,304-54,286,787 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues and 6 paralogues. Biased expression in lung (RPKM 13.1), skin (RPKM 8.6) and 10 other tissues.

Summary

IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009]

IRX3 Products(1)

mRNA Protein Name
NM_024336.3 NP_077312.2 iroquois-class homeodomain protein IRX-3
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRX3 Protein Structure

Homeobox_KN

Homeobox_KN: Homeobox KN domain (145 - 184)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
Protein Preferred Names Protein Names

iroquois-class homeodomain protein IRX-3

homeodomain protein IRXB1

Related Diseases

Diseases Alias
Aniseikonia
Transient Refractive Change
Cycloplegia

Ciliary Muscle Paresis

Cycloplegic Paralysis Of Accommodation

Paresis Of Accommodation

Visual Accommodation Paralysis

Accommodation Paralysis

Intrinsic Paralysis Of Eye Muscle

Cycloplegic
Eye Accommodation Disease
Keratoconus

Kc

Conical Cornea

Noninflammatory Corneal Thining

Bulging Cornea

Cornea Conical

Acquired Conus Of Cornea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06922 IRX3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IRX3 RGD RGD:1307424
Mus musculus IRX3 MGD MGI:1197522
Canis familiaris IRX3 VGNC VGNC:42102
Macaca mulatta IRX3 VGNC VGNC:99517
Bos taurus IRX3 VGNC VGNC:30287