LST1 - leukocyte specific transcript 1 Gene

Homo sapiens

Also known as B144; LST-1; D6S49E

Gene ID: 7940 | Gene type: protein coding

About LST1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,586,277-31,588,909 (from NCBI)

This gene has 21 transcripts (splice variants), 1 gene allele and 44 orthologues. Biased expression in bone marrow (RPKM 68.1), spleen (RPKM 43.9) and 13 other tissues.

Summary

The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

LST1 Products(6)

mRNA	Protein	Name
NM_001166538.1	NP_001160010.1	leukocyte-specific transcript 1 protein isoform 6
NM_007161.3	NP_009092.3	leukocyte-specific transcript 1 protein isoform 1
NM_205837.3	NP_995309.2	leukocyte-specific transcript 1 protein isoform 2
NM_205838.3	NP_995310.2	leukocyte-specific transcript 1 protein isoform 3
NM_205839.3	NP_995311.2	leukocyte-specific transcript 1 protein isoform 4
NM_205840.2	NP_995312.2	leukocyte-specific transcript 1 protein isoform 5

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in dendrite development	IDA IDA: Inferred from direct assay	11478849	GOA
involved in negative regulation of lymphocyte proliferation	IDA IDA: Inferred from direct assay	10706707	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11478849	GOA
located in membrane	IDA IDA: Inferred from direct assay	10706707	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LST1 Protein Structure

LST1

0
97 a.a.

Protein Preferred Names

Protein Names

leukocyte-specific transcript 1 protein

lymphocyte antigen 117

Related Diseases

Diseases

Alias

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07867	LST1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LST1	RGD	RGD:620077
Bos taurus	LST1	VGNC	VGNC:107291
Mus musculus	LST1	MGD	MGI:1096324

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