NOX5 - NADPH oxidase 5 Gene

Homo sapiens

Gene ID: 79400 | Gene type: protein coding

About NOX5

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:68,930,525-69,062,762 (from NCBI)

This gene has 6 transcripts (splice variants), 150 orthologues and 6 paralogues. Biased expression in spleen (RPKM 7.9), testis (RPKM 4.2) and 3 other tissues.

Summary

This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH Oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

NOX5 Products(3)

mRNA	Protein	Name
NM_001184779.2	NP_001171708.1	NADPH oxidase 5 isoform 2
NM_001184780.2	NP_001171709.1	NADPH oxidase 5 isoform 3
NM_024505.4	NP_078781.3	NADPH oxidase 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17346712	GOA
enables proton channel activity	IDA IDA: Inferred from direct assay	11483596	GOA
NOT contributes to superoxide-generating NAD(P)H oxidase activity	IDA IDA: Inferred from direct assay	22427510	GOA
enables superoxide-generating NAD(P)H oxidase activity	IDA IDA: Inferred from direct assay	11483596	GOA
enables superoxide-generating NAD(P)H oxidase activity	IMP IMP: Inferred from mutant phenotype	14982937	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IDA IDA: Inferred from direct assay	17275676	GOA
involved in endothelial cell proliferation	IDA IDA: Inferred from direct assay	17275676	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	17275676	GOA
involved in proton transmembrane transport	IDA IDA: Inferred from direct assay	11483596	GOA
involved in superoxide anion generation	IDA IDA: Inferred from direct assay	11483596	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17275676	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17587483	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOX5 Protein Structure

EF-hand_6

EF-hand_5

Ferric_reduct

FAD_binding_8

NAD_binding_6

0
200
400
600
765 a.a.

Protein Preferred Names

Protein Names

NADPH oxidase 5

NADPH oxidase, EF-hand calcium binding domain 5

Related Diseases

Diseases

Alias

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Barrett'S Adenocarcinoma

Barrett Adenocarcinoma

Adenocarcinoma Arising In Barrett'S Mucosa

Chronic Granulomatous Disease

Cgd	Granulomatous Disease, Chronic
Autosomal Recessive Chronic Granulomatous Disease	X-Linked Chronic Granulomatous Disease
Bridges-Good Syndrome	Congenital Dysphagocytosis
Quie Syndrome	Chronic Septic Granulomatosis
Chronic Granulomatous Disorder	Granulomatous Disease Chronic
Granulomatous Disease, Chronic, X-Linked

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0807A	Prochlorperazine dimaleate	Inhibitor	≥98.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09464	NOX5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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