ZBED2 - zinc finger BED-type containing 2 Gene

Homo sapiens

Gene ID: 79413 | Gene type: protein coding

About ZBED2

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:111,592,900-111,595,346 (from NCBI)

This gene has 1 transcript (splice variant) and 64 orthologues. Biased expression in thyroid (RPKM 46.0), lung (RPKM 7.6) and 2 other tissues.

Summary

Enables transcription cis-regulatory region binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of keratinocyte differentiation. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

ZBED2 Products(1)

mRNA	Protein	Name
NM_024508.5	NP_078784.2	zinc finger BED domain-containing protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	32385160	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	32385160	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	32385160	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	32385160	GOA
involved in positive regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	31552090	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBED2 Protein Structure

zf-BED

0
100
200
218 a.a.

Protein Preferred Names

Protein Names

zinc finger BED domain-containing protein 2

zinc finger, BED domain containing 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15955	ZBED2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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