HAUS3 - HAUS augmin like complex subunit 3 Gene

Homo sapiens

Also known as IT1; dgt3; C4orf15

Gene ID: 79441 | Gene type: protein coding

About HAUS3

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,228,349-2,242,121 (from NCBI)

This gene has 5 transcripts (splice variants) and 192 orthologues. Ubiquitous expression in bone marrow (RPKM 19.8), lymph node (RPKM 8.7) and 24 other tissues.

Summary

This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA Polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

HAUS3 Products(2)

mRNA	Protein	Name
NM_001303143.2	NP_001290072.1	HAUS augmin-like complex subunit 3
NM_024511.7	NP_078787.2	HAUS augmin-like complex subunit 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19369198	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	19427217	GOA
involved in spindle assembly	IMP IMP: Inferred from mutant phenotype	19369198	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of HAUS complex	IDA IDA: Inferred from direct assay	19369198	GOA
part of HAUS complex	IPI IPI: Inferred from physical interaction	20360068	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in mitotic spindle microtubule	IDA IDA: Inferred from direct assay	30723163	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAUS3 Protein Structure

HAUS-augmin3

0
100
200
300
400
500
603 a.a.

Protein Preferred Names

Protein Names

HAUS augmin-like complex subunit 3

HAUS3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HAUS3	Q68CZ6	GNG13	Homo sapiens	Q9P2W3	Validated Y2H	32296183
Intra	HAUS3	Q68CZ6	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	HAUS3	Q68CZ6	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	HAUS3	Q68CZ6	HAUS6	Homo sapiens	Q7Z4H7	TAP	24981860
Intra	HAUS3	Q68CZ6	TXLNA	Homo sapiens	P40222	Y2H Prey Pooling	32296183
Intra	HAUS3	Q68CZ6	TXLNA	Homo sapiens	P40222	Y2H Array	32296183
Intra	HAUS3	Q68CZ6	TXLNA	Homo sapiens	P40222	Validated Y2H	25416956
Intra	HAUS3	Q68CZ6	BRME1	Homo sapiens	Q0VDD7	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Baritosis

Deposition Of Barium In The Lungs

Inhalation Of Barytes

Cystic Basal Cell Carcinoma

Skin Cystic Basal Cell Carcinoma

Micronodular Basal Cell Carcinoma

Skin Micronodular Basal Cell Carcinoma

Basal Cell Carcinoma, Micronodular

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06015	HAUS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HAUS3	VGNC	VGNC:62756
Macaca mulatta	HAUS3	VGNC	VGNC:73252
Canis familiaris	HAUS3	VGNC	VGNC:41604
Rattus norvegicus	HAUS3	RGD	RGD:1591723
Mus musculus	HAUS3	MGD	MGI:2387633
Bos taurus	HAUS3	VGNC	VGNC:29759

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