2. Gene
  3. LRRC2 - leucine rich repeat containing 2 Gene

LRRC2 - leucine rich repeat containing 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 79442 | Gene type: protein coding

About LRRC2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,515,385-46,566,302 (from NCBI)

This gene has 5 transcripts (splice variants), 192 orthologues and 31 paralogues. Biased expression in heart (RPKM 15.6), thyroid (RPKM 11.1) and 9 other tissues.

Summary

This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the Ras suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Sep 2011]

LRRC2 Products(1)

mRNA Protein Name
NM_024512.5 NP_078788.2 leucine-rich repeat-containing protein 2

LRRC2 Protein Structure

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (147 - 184)

LRR_1

LRR_1: Leucine Rich Repeat (191 - 213)

LRR_8

LRR_8: Leucine rich repeat (216 - 272)

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  • 371 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat-containing protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07810 LRRC2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LRRC2 VGNC VGNC:110357
Rattus norvegicus LRRC2 RGD RGD:1311716
Canis familiaris LRRC2 VGNC VGNC:81275
Mus musculus LRRC2 MGD MGI:1921499
Felis catus LRRC2 VGNC VGNC:80613
Bos taurus LRRC2 VGNC VGNC:59173
Others LRRC2 NCBI