NDNF - neuron derived neurotrophic factor Gene

Homo sapiens

Also known as HH25; NORD; C4orf31

Gene ID: 79625 | Gene type: protein coding

About NDNF

Cytogenetic location: 4q27 Genomic coordinates (GRCh38): 4:121,035,613-121,072,535 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and is associated with 3 phenotypes. Biased expression in lung (RPKM 64.4), placenta (RPKM 31.0) and 9 other tissues.

Summary

Predicted to enable heparin binding activity. Involved in several processes, including cellular response to hypoxia; negative regulation of apoptotic process; and nitric oxide mediated signal transduction. Located in extracellular space. Implicated in hypogonadotropic hypogonadism. [provided by Alliance of Genome Resources, Apr 2022]

NDNF Products(1)

mRNA	Protein	Name
NM_024574.4	NP_078850.3	protein NDNF precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IDA IDA: Inferred from direct assay	24706764	GOA
involved in cellular response to fibroblast growth factor stimulus	IMP IMP: Inferred from mutant phenotype	31883645	GOA
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	24706764	GOA
involved in negative regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	24706764	GOA
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	20969804	GOA
involved in neuron migration	IDA IDA: Inferred from direct assay	20969804	GOA
involved in nitric oxide mediated signal transduction	IDA IDA: Inferred from direct assay	24706764	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	20969804	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	20969804	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	35037619	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	31883645	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDNF Protein Structure

DUF2369

0
100
200
300
400
500
568 a.a.

Protein Preferred Names

Protein Names

protein NDNF

fibronectin type-III domain-containing protein C4orf31

Related Diseases

Diseases

Alias

Hypogonadotropic Hypogonadism 25 With Anosmia

HH25

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Hypogonadotropic Hypogonadism

Klinefelter Syndrome	Klinefelter'S Syndrome
Xxy Syndrome	Xxy Trisomy
Hypogonadotropism	47, Xxy
Congenital Idiopathic Hypogonadotropic Hypogonadism	Isolated Congenital Gonadotropin Deficiency
47,Xxy Syndrome	47, Xxy Syndrome
Klinefelters Syndrome	Hypogonadism
Klinefelter Syndrome In Males	Klinefelter Syndrome, Unspecified
Klinefelter Syndrome Karyotype 47, Xxy

Hypogonadism

Arthrogryposis, Distal, Type 1b

DA1B	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1b

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1	Digitotalar Dysmorphism
DA1A	Da1
Amcd1	Arthrogryposis, Distal, Type 2b4
Distal Arthrogryposis Type 1a	Arthrogryposis, Distal, Type 1
Arthrogryposis Multiplex Congenita Distal Type 1	Arthrogryposis Multiplex Congenita, Distal Type 1
Arthrogryposis Multiplex Congenita, Distal, Type I	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1a	Amc
Arthrogryposis Multiplex Congenita	Arthrogryposis, Distal, 2b4
DA2B4	Arthrogryposis Multiplex Congenita, Distal, Type 1
Arthrogryposis

Retinitis Pigmentosa 19

RP19	Retinitis Pigmentosa-19
Retinitis Pigmentosa, Type 19

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09111	NDNF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NDNF	VGNC	VGNC:31937
Mus musculus	NDNF	MGD	MGI:1915419
Macaca mulatta	NDNF	VGNC	VGNC:75027
Canis familiaris	NDNF	VGNC	VGNC:43676
Felis catus	NDNF	VGNC	VGNC:63752
Rattus norvegicus	NDNF	RGD	RGD:1311080

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