ZDHHC14 - zinc finger DHHC-type palmitoyltransferase 14 Gene

Homo sapiens

Also known as NEW1CP

Gene ID: 79683 | Gene type: protein coding

About ZDHHC14

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:157,381,190-157,678,157 (from NCBI)

This gene has 9 transcripts (splice variants), 198 orthologues and 17 paralogues. Ubiquitous expression in brain (RPKM 2.5), endometrium (RPKM 2.3) and 24 other tissues.

Summary

Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

ZDHHC14 Products(2)

mRNA	Protein	Name
NM_024630.3	NP_078906.2	palmitoyltransferase ZDHHC14 isoform 1
NM_153746.2	NP_714968.1	palmitoyltransferase ZDHHC14 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables palmitoyltransferase activity	IDA IDA: Inferred from direct assay	23034182	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptidyl-L-cysteine S-palmitoylation	IMP IMP: Inferred from mutant phenotype	27481942	GOA
involved in protein palmitoylation	IDA IDA: Inferred from direct assay	23034182	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16647879	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC14 Protein Structure

DHHC

0
100
200
300
400
488 a.a.

Protein Preferred Names

Protein Names

palmitoyltransferase ZDHHC14

DHHC domain-containing cysteine-rich protein 14

Related Diseases

Diseases

Alias

Chromosome 6q24-Q25 Deletion Syndrome

Chromosome 6q25-Q25 Deletion Syndrome	6q25 Microdeletion Syndrome
Monosomy 6q25	Del(6)(Q25)

Trichothiodystrophy 3, Photosensitive

TTD3	Trichothiodystrophy, Complementation Group A
Ttda	Photosensitive Trichothiodystrophy 3
Trichothiodystrophy Complementation Group A

Coffin-Siris Syndrome 1

Coffin-Siris Syndrome	Fifth Digit Syndrome
Css	CSS1
Mrd12	Mental Retardation, Autosomal Dominant 12
Hhid	Dwarfism-Onychodysplasia
Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features	Autosomal Dominant Mental Retardation 12
Short Stature-Onychodysplasia.	Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx
Mental Retardation With Hypoplastic Fifth Fingernails And Toenails	Short Stature-Onychodysplasia
Coffin-Siris Syndrome, Type 1	Mental Retardation, Autosomal Dominant, Type 12

Lung Acinar Adenocarcinoma

Acinar Adenocarcinoma Of The Lung

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16014	ZDHHC14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ZDHHC14	VGNC	VGNC:67203
Rattus norvegicus	ZDHHC14	RGD	RGD:1565877
Mus musculus	ZDHHC14	MGD	MGI:2653229
Bos taurus	ZDHHC14	VGNC	VGNC:37129
Macaca mulatta	ZDHHC14	VGNC	VGNC:82270
Canis familiaris	ZDHHC14	VGNC	VGNC:48580

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