GAL3ST4 - galactose-3-O-sulfotransferase 4 Gene

Homo sapiens

Also known as GAL3ST-4

Gene ID: 79690 | Gene type: protein coding

About GAL3ST4

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,159,244-100,168,617 (from NCBI)

This gene has 8 transcripts (splice variants), 202 orthologues and 3 paralogues. Ubiquitous expression in skin (RPKM 11.3), salivary gland (RPKM 5.3) and 21 other tissues.

Summary

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This Enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. [provided by RefSeq, Jul 2008]

GAL3ST4 Products(1)

mRNA	Protein	Name
NM_024637.5	NP_078913.3	galactose-3-O-sulfotransferase 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables galactose 3-O-sulfotransferase activity	IDA IDA: Inferred from direct assay	11333265	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within glycoprotein biosynthetic process	IDA IDA: Inferred from direct assay	11333265	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	11333265	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAL3ST4 Protein Structure

Gal-3-0_sulfotr

0
100
200
300
400
486 a.a.

Protein Preferred Names

Protein Names

galactose-3-O-sulfotransferase 4

beta-galactose-3-O-sulfotransferase 4

Related Diseases

Diseases

Alias

Fanconi Anemia, Complementation Group G

Fanconi Anemia Complementation Group G

FANCG

Scoliosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05240	GAL3ST4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GAL3ST4	VGNC	VGNC:54026
Mus musculus	GAL3ST4	MGD	MGI:1916254
Rattus norvegicus	GAL3ST4	RGD	RGD:1561105
Macaca mulatta	GAL3ST4	VGNC	VGNC:72770
Felis catus	GAL3ST4	VGNC	VGNC:62437
Bos taurus	GAL3ST4	VGNC	VGNC:29216

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