NSUN7 - NOP2/Sun RNA methyltransferase family member 7 Gene

Homo sapiens

Gene ID: 79730 | Gene type: protein coding

About NSUN7

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:40,749,955-40,811,184 (from NCBI)

This gene has 7 transcripts (splice variants) and 213 orthologues. Broad expression in testis (RPKM 10.8), thyroid (RPKM 2.4) and 19 other tissues.

Summary

Predicted to enable RNA binding activity and methyltransferase activity. Predicted to be involved in methylation. Predicted to act upstream of or within flagellated sperm motility and sperm mitochondrion organization. [provided by Alliance of Genome Resources, Apr 2022]

NSUN7 Products(2)

mRNA	Protein	Name
NM_001330648.3	NP_001317577.1	putative methyltransferase NSUN7 isoform 2
NM_024677.6	NP_078953.4	putative methyltransferase NSUN7 isoform 1

NSUN7 Protein Structure

Methyltr_RsmB-F

0
200
400
600
718 a.a.

Protein Preferred Names

Protein Names

putative methyltransferase NSUN7

NOL1/NOP2/Sun domain family member 7

Related Diseases

Diseases

Alias

Dubowitz Syndrome

Dubowitz'S Syndrome	Dwarfism-Eczema-Peculiar Facies Syndrome
Intrauterine Growth Restriction, Short Stature, Microcephaly, Mild Intellectual Disability With Behavior Problems, Eczema, And Unusual And Distinctive Faci

Cardiomyopathy, Familial Restrictive, 1

RCM1	Restrictive Cardiomyopathy 1
Rcm	Familial Restrictive Cardiomyopathy 1
Cardiomyopathy, Familial Restrictive 1	Cardiomyopathy, Restrictive, Familial, Type 1
Rcm-1

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09606	NSUN7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NSUN7	VGNC	VGNC:75463
Rattus norvegicus	NSUN7	RGD	RGD:1310137
Mus musculus	NSUN7	MGD	MGI:1918168
Bos taurus	NSUN7	VGNC	VGNC:32288
Canis familiaris	NSUN7	VGNC	VGNC:43993
Felis catus	NSUN7	VGNC	VGNC:63896

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