ZNF750 - zinc finger protein 750 Gene

Homo sapiens

Also known as SLDPE; ZFP750

Gene ID: 79755 | Gene type: protein coding

About ZNF750

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,829,434-82,840,022 (from NCBI)

This gene has 2 transcripts (splice variants), 202 orthologues, 2 paralogues and is associated with 3 phenotypes. Biased expression in esophagus (RPKM 37.2), skin (RPKM 25.3) and 5 other tissues.

Summary

This gene encodes a protein with a nuclear localization site and a C2H2 zinc finger domain. Mutations in this gene have been associated with seborrhea-like dermatitis with psoriasiform elements. [provided by RefSeq, Jul 2008]

ZNF750 Products(1)

mRNA	Protein	Name
NM_024702.3	NP_078978.2	zinc finger protein 750

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22364861	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	32042337	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22364861	GOA
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	27907090	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in epidermis development	IMP IMP: Inferred from mutant phenotype	22364861	GOA
involved in negative regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	32042337	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	32042337	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22364861	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	27907090	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	22364861	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF750 Protein Structure

zf-C2H2_7

0
200
400
600
723 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 750

protein ZNF750

Related Diseases

Diseases

Alias

Seborrhea-Like Dermatitis With Psoriasiform Elements

SLDP

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Seborrheic Dermatitis

Seborrhoeic Dermatitis	Seborrhea
Seborrhoeic Eczema	Skin Seborrheic
Dermatitis, Seborrheic

Rectosigmoid Junction Neoplasm

Neoplasm Of Rectosigmoid Junction	Rectosigmoid Neoplasm
Rectosigmoid Tumor	Rectosigmoid Carcinoma
Carcinoma Of The Rectosigmoid Junction	Malignant Tumor Of Rectosigmoid Junction
Rectosigmoid Junction Cancer	Primary Malignant Neoplasm Of Rectosigmoid Junction
Rectosigmoid Colon Cancer	Carcinoma Of Rectum With Sigmoid
Colorectal Cancer Nos	Colorectal Carcinoma Nos
Rectosigmoid Cancer

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Sigmoid Neoplasm

Sigmoid Neoplasms	Neoplasm Of Sigmoid Colon
Tumor Of Sigmoid Colon

Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lung	Squamous Cell Lung Carcinoma
Epidermoid Cell Carcinoma Of The Lung	Squamous Cell Lung Cancer

Eyelid Carcinoma

Carcinoma Of The Eyelid

Seborrheic Infantile Dermatitis

Cradle Cap	Infantile Seborrhoeic Dermatitis
Seborrhoea Capitis	Seborrhoeic Dermatitis Of Scalp
Seborrhoeic Eczema Of Scalp	Complement 5 Dysfunction
Generalized Seborrheic Dermatitis Of Infants	Infantile Seborrheic Dermatitis
Pityriasis Capitis	Seborrhea Capitis
Seborrhea Sicca	Dandruff
Complement Component 5 Deficiency	Seborrheic Dermatitis
Seborrheic Dermatitis Of Scalp	Scurfiness Of Scalp
Seborrheic Dermatitis Of Infancy	Infantile Seborrhoeic Eczema
Neonatal Seborrhoeic Dermatitis	Infantile Seborrhoeic Dermatitis Of The Scalp

Muir-Torre Syndrome

MRTES	Keratoacanthoma
Muir-Torré Syndrome	Cutaneous Sebaceous Neoplasms And Keratoacanthomas, Multiple, With Gastrointestinal And Other Carcinomas
Cutaneous Sebaceous Neoplasms And Keratoacanthomas Multiple With Gastrointestinal And Other Carcinomas	Multiple Keratoacanthoma, Muir-Torre Type
Mts	Torre-Muir Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16173	ZNF750 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZNF750	RGD	RGD:1590044
Mus musculus	ZNF750	MGD	MGI:2442210
Felis catus	ZNF750	VGNC	VGNC:67354
Canis familiaris	ZNF750	VGNC	VGNC:48810
Bos taurus	ZNF750	VGNC	VGNC:37340
Macaca mulatta	ZNF750	VGNC	VGNC:104679

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