VASH2 - vasohibin 2 Gene

Homo sapiens

Gene ID: 79805 | Gene type: protein coding

About VASH2

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,950,541-212,991,585 (from NCBI)

This gene has 12 transcripts (splice variants), 200 orthologues and 1 paralogue. Broad expression in testis (RPKM 1.7), esophagus (RPKM 1.3) and 20 other tissues.

Summary

Enables actin binding activity; metallocarboxypeptidase activity; and microtubule binding activity. Involved in axon development and proteolysis. Acts upstream of or within cell-cell fusion; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

VASH2 Products(4)

mRNA	Protein	Name
NM_001136474.3	NP_001129946.1	tubulinyl-Tyr carboxypeptidase 2 isoform 2
NM_001136475.3	NP_001129947.1	tubulinyl-Tyr carboxypeptidase 2 isoform 3
NM_001301056.2	NP_001287985.1	tubulinyl-Tyr carboxypeptidase 2 isoform 4
NM_024749.5	NP_079025.2	tubulinyl-Tyr carboxypeptidase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	29146869	GOA
enables metallocarboxypeptidase activity	IDA IDA: Inferred from direct assay	29146869	GOA
enables metallocarboxypeptidase activity	IMP IMP: Inferred from mutant phenotype	31171830	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	31324789	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	29146869	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon development	IMP IMP: Inferred from mutant phenotype	31324789	GOA
acts upstream of or within cell-cell fusion	IDA IDA: Inferred from direct assay	25184477	GOA
acts upstream of or within cell-cell fusion	IMP IMP: Inferred from mutant phenotype	25184477	GOA
acts upstream of or within positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	19204325	GOA
acts upstream of or within positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	19204325	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	29146869	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19204325	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VASH2 Protein Structure

Vasohibin

0
100
200
300
355 a.a.

Protein Preferred Names

Protein Names

tubulinyl-Tyr carboxypeptidase 2

testicular tissue protein Li 222

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15607	VASH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VASH2	MGD	MGI:2444826
Bos taurus	VASH2	VGNC	VGNC:36768
Rattus norvegicus	VASH2	RGD	RGD:1564105
Felis catus	VASH2	VGNC	VGNC:81206
Macaca mulatta	VASH2	VGNC	VGNC:79532
Canis familiaris	VASH2	VGNC	VGNC:48234

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