2. Gene
  3. ST7 - suppression of tumorigenicity 7 Gene

ST7 - suppression of tumorigenicity 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HELG; RAY1; SEN4; TSG7; ETS7q; FAM4A; FAM4A1

Gene ID: 7982 | Gene type: protein coding

About ST7

Cytogenetic location: 7q31.2 Genomic coordinates (GRCh38): 7:116,953,501-117,230,176 (from NCBI)

This gene has 28 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 11.1), lung (RPKM 10.9) and 25 other tissues.

Summary

The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

ST7 Products(11)

mRNA Protein Name
NM_001369598.1 NP_001356527.1 suppressor of tumorigenicity 7 protein isoform 3
NM_001369599.1 NP_001356528.1 suppressor of tumorigenicity 7 protein isoform 1
NM_001369600.1 NP_001356529.1 suppressor of tumorigenicity 7 protein isoform 2
NM_001369601.1 NP_001356530.1 suppressor of tumorigenicity 7 protein isoform 4
NM_001369602.1 NP_001356531.1 suppressor of tumorigenicity 7 protein isoform 6
NM_001369603.1 NP_001356532.1 suppressor of tumorigenicity 7 protein isoform 7
NM_001369604.1 NP_001356533.1 suppressor of tumorigenicity 7 protein isoform 9
NM_001369606.1 NP_001356535.1 suppressor of tumorigenicity 7 protein isoform 10
NM_001369607.1 NP_001356536.1 suppressor of tumorigenicity 7 protein isoform 11
NM_018412.4 NP_060882.2 suppressor of tumorigenicity 7 protein isoform 5
NM_021908.3 NP_068708.1 suppressor of tumorigenicity 7 protein isoform 8
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
30945288 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST7 Protein Structure

ST7

ST7: ST7 protein (16 - 570)

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  • 585 a.a.
Protein Preferred Names Protein Names

suppressor of tumorigenicity 7 protein

family with sequence similarity 4, subfamily A, member 1

Related Diseases

Diseases Alias
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Gastric Dilatation

Stomach Dilatation
Facial Neuralgia
Neurilemmoma Of The Fifth Cranial Nerve

Trigeminal Schwannoma

Trigeminal Neurilemmoma
Trigeminal Nerve Neoplasm

Neoplasm Of Trigeminal Nerve

Tumor Of Trigeminal Nerve
Duodenal Obstruction
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13854 ST7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13855 ST7L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ST7 VGNC VGNC:49974
Felis catus ST7 VGNC VGNC:65734
Macaca mulatta ST7 VGNC VGNC:77899
Rattus norvegicus ST7 RGD RGD:1303148
Mus musculus ST7 MGD MGI:1927450
Canis familiaris ST7 VGNC VGNC:49656
Others ST7 NCBI