CLMP - CXADR like membrane protein Gene

Homo sapiens

Also known as ACAM; ASAM; CSBM; CSBS

Gene ID: 79827 | Gene type: protein coding

About CLMP

Cytogenetic location: 11q24.1 Genomic coordinates (GRCh38): 11:123,069,872-123,195,248 (from NCBI)

This gene has 4 transcripts (splice variants), 397 orthologues, 14 paralogues and is associated with 3 phenotypes. Broad expression in fat (RPKM 45.1), endometrium (RPKM 20.9) and 17 other tissues.

Summary

This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome. [provided by RefSeq, Aug 2015]

CLMP Products(1)

mRNA	Protein	Name
NM_024769.5	NP_079045.1	CXADR-like membrane protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in digestive tract development	IMP IMP: Inferred from mutant phenotype	22155368	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	22155368	GOA
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	23264731	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLMP Protein Structure

V-set

Ig_2

0
100
200
300
373 a.a.

Protein Preferred Names

Protein Names

CXADR-like membrane protein

CAR-like membrane protein

CLMP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CLMP	Q9H6B4	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	CLMP	Q9H6B4	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLMP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7609	ASAM/CLMP Protein, Human (HEK293, His)	Q9H6B4 (T19-M233)	≥95%

Related Diseases

Diseases

Alias

Congenital Short Bowel Syndrome

CSBS	Congenital Short Bowel
Congenital Short Bowel And Malrotation Syndrome	Csbm
Bowel, Short, Syndrome, Congenital	Intestinal Pseudo-Obstruction

Intestinal Pseudo-Obstruction

Chronic Intestinal Pseudoobstruction	Chronic Intestinal Pseudo-Obstruction
Cipo	Neuronal Intestinal Dysplasia
Hollow Visceral Myopathy	Familial Visceral Neuropathy
Paralytic Ileus	Intestinal Pseudoobstruction
Chronic Idiopathic Intestinal Pseudo-Obstruction	Ciip
Congenital Short Bowel Syndrome	Enteric Neuropathy
Familial Visceral Myopathy	Ipo
Pseudo-Obstruction Of Intestine	Pseudointestinal Obstruction Syndrome
Pseudoobstructive Syndrome	Congenital Idiopathic Intestinal Pseudoobstruction
Visceral Myopathy, Familial

Short Bowel Syndrome

Short Gut Syndrome	Acquired Short Bowel Syndrome
Secondary Short Bowel Syndrome	Short Bowel Nos

Interstitial Myocarditis

Testicular Thecoma

Cataract 4, Multiple Types

Cataract 4 Multiple Types	CTRCT4
Cca3	Pcc
Aculeiform Cataract	Cataract 4, Multiple Types, With Or Without Microcornea
Cataract, Crystalline Aculeiform	Caca
Cataract, Congenital, Cerulean Type, 3	Congenital Cataract Cerulean Type 3
Cataract Congenital Dominant Non Nuclear	Ccp
Cataract, Nonnuclear Polymorphic Congenital	Cataract, Punctate, Progressive Juvenile-Onset
Cataract 4 Multiple Types With Or Without Microcornea	Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract
Cataract, Polymorphic Congenital	Congenital Cataract Blue Dot Type 3
Congenital Non-Nuclear Polymorphic Cataract	Crystalline Aculeiform Cataract
Punctate, Progressive Juvenile-Onset, Cataract	Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant

Trichothiodystrophy

Ttd	Amish Brittle Hair Syndrome
Bids Syndrome	Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome
Ibids	Pibids
Trichothiodystrophy Syndromes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02821	CLMP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CLMP	VGNC	VGNC:71328
Felis catus	CLMP	VGNC	VGNC:60967
Mus musculus	CLMP	MGD	MGI:1918816
Bos taurus	CLMP	VGNC	VGNC:50091
Rattus norvegicus	CLMP	RGD	RGD:708569
Others	CLMP	NCBI

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