AGBL2 - AGBL carboxypeptidase 2 Gene

Homo sapiens

Also known as CCP2

Gene ID: 79841 | Gene type: protein coding

About AGBL2

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,659,591-47,715,369 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 191 orthologues and 5 paralogues. Biased expression in testis (RPKM 8.5), lung (RPKM 1.3) and 7 other tissues.

Summary

Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in protein side chain deglutamylation. Located in centriole and ciliary basal body. [provided by Alliance of Genome Resources, Apr 2022]

AGBL2 Products(1)

mRNA	Protein	Name
NM_024783.4	NP_079059.2	cytosolic carboxypeptidase 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21303978	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriole	IDA IDA: Inferred from direct assay	23085998	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	23085998	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGBL2 Protein Structure

Peptidase_M14

0
200
400
600
800
902 a.a.

Protein Preferred Names

Protein Names

cytosolic carboxypeptidase 2

ATP/GTP binding protein like 2

Related Diseases

Diseases

Alias

Palindromic Rheumatism

Hench'S Syndrome	Hench-Rosenberg Syndrome
Palindromic Rheumatism Syndrome	Palindromic Arthritis

Tenosynovitis

Inflammation Of Tendon Sheath

Synovitis Or Tenosynovitis

Periarthritis

3mc Syndrome

Craniofacial-Ulnar-Renal Syndrome	Malpuech Facial Clefting Syndrome
Oculopalatoskeletal Syndrome	Carnevale Syndrome
Michels Syndrome	Malpuech-Michels-Mingarelli-Carnevale Syndrome
Carnevale-Krajewska-Fischetto Syndrome	Craniosynostosis With Lid Anomalies
Malpuech Syndrome	Mingarelli Syndrome
Oculo-Skeletal-Abdominal Syndrome	Osa Syndrome
Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia	Ptosis-Strabismus-Rectus Abdominis Diastasis

Crest Syndrome

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00441	AGBL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	AGBL2	VGNC	VGNC:99539
Mus musculus	AGBL2	MGD	MGI:2443254
Bos taurus	AGBL2	VGNC	VGNC:106635
Felis catus	AGBL2	VGNC	VGNC:59677
Canis familiaris	AGBL2	VGNC	VGNC:37696
Rattus norvegicus	AGBL2	RGD	RGD:1306827

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