TREML2 - triggering receptor expressed on myeloid cells like 2 Gene

Homo sapiens

Also known as TLT2; TLT-2; C6orf76; dJ238O23.1

Gene ID: 79865 | Gene type: protein coding

About TREML2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,189,749-41,201,149 (from NCBI)

This gene has 1 transcript (splice variant), 105 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 5.6), lymph node (RPKM 5.1) and 6 other tissues.

Summary

TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]

TREML2 Products(1)

mRNA	Protein	Name
NM_024807.4	NP_079083.2	trem-like transcript 2 protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18650384	GOA
enables signaling receptor activity	IDA IDA: Inferred from direct assay	18650384	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell activation	IDA IDA: Inferred from direct assay	18650384	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	18650384	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TREML2 Protein Structure

V-set

0
100
200
300
321 a.a.

Protein Preferred Names

Protein Names

trem-like transcript 2 protein

triggering receptor expressed on myeloid cells-like protein 2

Recombinant TREML2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71383	TREML2 Protein, Human (HEK293, Fc)	Q5T2D2 (G19-S268)	≥95%

Related Diseases

Diseases

Alias

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease	Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Plosl	Nhd
Presenile Dementia With Bone Cysts	Plo-Sl
PLOSL1	Dementia, Prefrontal, With Bone Cysts
Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease
Progressive Dementia With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15005	TREML2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TREML2	RGD	RGD:1587039
Canis familiaris	TREML2	VGNC	VGNC:47795
Mus musculus	TREML2	MGD	MGI:2147038
Macaca mulatta	TREML2	VGNC	VGNC:79309
Bos taurus	TREML2	VGNC	VGNC:36301
Others	TREML2	NCBI

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