2. Gene
  3. CALCR - calcitonin receptor Gene

CALCR - calcitonin receptor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CRT; CTR; CT-R; CTR1

Gene ID: 799 | Gene type: protein coding

About CALCR

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,424,486-93,574,724 (from NCBI)

This gene has 5 transcripts (splice variants), 218 orthologues, 42 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene encodes a high affinity receptor for the peptide hormone Calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

CALCR Products(3)

mRNA Protein Name
NM_001164737.3 NP_001158209.2 calcitonin receptor isoform 1 precursor
NM_001164738.2 NP_001158210.1 calcitonin receptor isoform 2 precursor
NM_001742.4 NP_001733.1 calcitonin receptor isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables amylin receptor activity IGI
IGI: Inferred from genetic interaction
22500019 GOA
enables amylin receptor activity IPI
IPI: Inferred from physical interaction
14722252 GOA
enables amyloid-beta binding IDA
IDA: Inferred from direct assay
22500019 GOA
NOT enables calcitonin binding IDA
IDA: Inferred from direct assay
15563840 GOA
enables calcitonin binding IDA
IDA: Inferred from direct assay
7769107 GOA
enables calcitonin binding IPI
IPI: Inferred from physical interaction
7588285 GOA
enables calcitonin gene-related peptide receptor activity IPI
IPI: Inferred from physical interaction
14722252 GOA
enables calcitonin receptor activity IDA
IDA: Inferred from direct assay
7588285 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7588285 GOA
Biological Process GO Annotation Evidence Reference Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
7619207 GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in amylin receptor signaling pathway IDA
IDA: Inferred from direct assay
14722252 GOA
involved in amylin receptor signaling pathway IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in calcitonin gene-related peptide receptor signaling pathway IDA
IDA: Inferred from direct assay
7588285 GOA
involved in positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in positive regulation of cAMP/PKA signal transduction IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in positive regulation of calcium-mediated signaling IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
8078488 GOA
involved in positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in response to amyloid-beta IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in response to glucocorticoid IDA
IDA: Inferred from direct assay
11250927 GOA
Cellular Component GO Annotation Evidence Reference Source
part of amylin receptor complex 1 IDA
IDA: Inferred from direct assay
22500019 GOA
part of amylin receptor complex 2 IDA
IDA: Inferred from direct assay
22500019 GOA
part of amylin receptor complex 3 IDA
IDA: Inferred from direct assay
22500019 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALCR Protein Structure

HRM

HRM: Hormone receptor domain (87 - 153)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (209 - 421)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

calcitonin receptor

Recombinant CALCR Proteins

Cat. No. Product Name Accession Purity
HY-P74359 Calcitonin R Protein, Human (HEK293, hFc) P30988 (A25-V154) ≥95%

Related Diseases

Diseases Alias
Holoprosencephaly 6

HPE6
Bone Mineral Density Quantitative Trait Locus 15

Osteoporosis

BMND15

Osteoporosis, Susceptibility To

Metaphyseal Fracture

Metaphyseal Fracture, Susceptibility To

Compression Fracture

Compression Fracture, Susceptibility To

Metaphyseal Fractures

Fractures, Compression
Root Resorption
Urolithiasis
Psoriasis 11

PSORS11

Psoriasis 11, Susceptibility To

Psoriasis Susceptibility 11

Psoriasis

Psoriasis Vulgaris

Pv
Giant Cell Reparative Granuloma

Central Giant Cell Granuloma

Central Giant Cell Reparative Granuloma Of Jaw

Central Giant Cell Granuloma

Granuloma, Giant Cell

Granuloma, Giant Cell Reparative

Giant Cell Lesion Of Small Bones

Giant Cell Granuloma, Nos
Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis
Bone Giant Cell Tumor

Giant Cell Tumor Of Bone

Osteoclastoma

Gct Of Bone

Bone Giant Cell Tumour

Giant Cell Myeloma

Giant Cell Neoplasm Of Bone

Giant Cell Tumour Of Bone
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Colon Leiomyoma

Colonic Leiomyoma
Mixed Cerebral Palsy

Cerebral Palsy, Mixed
Moyamoya Disease 1

Moyamoya Disease

Spontaneous Occlusion Of The Circle Of Willis

Mymy

Progressive Intracranial Arterial Occlusion

Moyamoya Syndrome

MYMY1

Cerebrovascular Moyamoya Disease

Moya-Moya Disease

Progressive Intracranial Occlusive Arteropathy

Idiopathic Moyamoya Disease
Osteopetrosis

Albers-Schonberg Disease

Marble Bone Disease

Osteopetroses

Marble Bones

Osteopetrosis And Related Disorders

Congenital Osteopetrosis

Marble Bone

Albers-Schoenberg Disease

Albers-Schonberg Osteopetrosis

Osteosclerosis Fragilis

Ivory Bones
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01832 CALCR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01833 Calcr Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01834 Calcr Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CALCR MGD MGI:101950
Macaca mulatta CALCR VGNC VGNC:70516
Felis catus CALCR VGNC VGNC:60321
Canis familiaris CALCR VGNC VGNC:38664
Rattus norvegicus CALCR RGD RGD:621001
Bos taurus CALCR VGNC VGNC:26704
Others CALCR NCBI