CALCR - calcitonin receptor Gene

Homo sapiens

Also known as CRT; CTR; CT-R; CTR1

Gene ID: 799 | Gene type: protein coding

About CALCR

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,424,486-93,574,724 (from NCBI)

This gene has 5 transcripts (splice variants), 218 orthologues, 42 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene encodes a high affinity receptor for the peptide hormone Calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

CALCR Products(3)

mRNA	Protein	Name
NM_001164737.3	NP_001158209.2	calcitonin receptor isoform 1 precursor
NM_001164738.2	NP_001158210.1	calcitonin receptor isoform 2 precursor
NM_001742.4	NP_001733.1	calcitonin receptor isoform 2 precursor

CALCR Protein Structure

HRM

7tm_2

0
100
200
300
400
508 a.a.

Protein Preferred Names

Protein Names

calcitonin receptor

Recombinant CALCR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74359	Calcitonin R Protein, Human (HEK293, hFc)	P30988 (A25-V154)	≥95%

Related Diseases

Diseases

Alias

Holoprosencephaly 6

HPE6

Bone Mineral Density Quantitative Trait Locus 15

Osteoporosis	BMND15
Osteoporosis, Susceptibility To	Metaphyseal Fracture
Metaphyseal Fracture, Susceptibility To	Compression Fracture
Compression Fracture, Susceptibility To	Metaphyseal Fractures
Fractures, Compression

Root Resorption

Urolithiasis

Psoriasis 11

PSORS11	Psoriasis 11, Susceptibility To
Psoriasis Susceptibility 11	Psoriasis
Psoriasis Vulgaris	Pv

Giant Cell Reparative Granuloma

Central Giant Cell Granuloma	Central Giant Cell Reparative Granuloma Of Jaw
Central Giant Cell Granuloma	Granuloma, Giant Cell
Granuloma, Giant Cell Reparative	Giant Cell Lesion Of Small Bones
Giant Cell Granuloma, Nos

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Bone Giant Cell Tumor

Giant Cell Tumor Of Bone	Osteoclastoma
Gct Of Bone	Bone Giant Cell Tumour
Giant Cell Myeloma	Giant Cell Neoplasm Of Bone
Giant Cell Tumour Of Bone

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Colon Leiomyoma

Colonic Leiomyoma

Mixed Cerebral Palsy

Cerebral Palsy, Mixed

Moyamoya Disease 1

Moyamoya Disease	Spontaneous Occlusion Of The Circle Of Willis
Mymy	Progressive Intracranial Arterial Occlusion
Moyamoya Syndrome	MYMY1
Cerebrovascular Moyamoya Disease	Moya-Moya Disease
Progressive Intracranial Occlusive Arteropathy	Idiopathic Moyamoya Disease

Osteopetrosis

Albers-Schonberg Disease	Marble Bone Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01832	CALCR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01833	Calcr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01834	Calcr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CALCR	MGD	MGI:101950
Macaca mulatta	CALCR	VGNC	VGNC:70516
Felis catus	CALCR	VGNC	VGNC:60321
Canis familiaris	CALCR	VGNC	VGNC:38664
Rattus norvegicus	CALCR	RGD	RGD:621001
Bos taurus	CALCR	VGNC	VGNC:26704
Others	CALCR	NCBI

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