WDR76 - WD repeat domain 76 Gene

Homo sapiens

Also known as CDW14

Gene ID: 79968 | Gene type: protein coding

About WDR76

This gene has 4 transcripts (splice variants) and 198 orthologues. Broad expression in lymph node (RPKM 6.6), bone marrow (RPKM 3.7) and 23 other tissues.

Summary

Enables Enzyme binding activity. Involved in cellular response to DNA damage stimulus. Located in heterochromatin; nucleus; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

WDR76 Products(2)

mRNA	Protein	Name
NM_001167941.2	NP_001161413.1	WD repeat-containing protein 76 isoform 2
NM_024908.4	NP_079184.2	WD repeat-containing protein 76 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	27248496	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27248496	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	27248496	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in heterochromatin	IMP IMP: Inferred from mutant phenotype	27248496	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27248496	GOA
located in site of DNA damage	IMP IMP: Inferred from mutant phenotype	27248496	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR76 Protein Structure

WD40

0
100
200
300
400
500
626 a.a.

Protein Preferred Names

Protein Names

WD repeat-containing protein 76

Related Diseases

Diseases

Alias

Congenital Disorder Of Glycosylation, Type Ig

CDG1G	Alg12-Congenital Disorder Of Glycosylation
Cdg Ig	Congenital Disorder Of Glycosylation Type 1g
Congenital Disorder Of Glycosylation Type Ig	Cdgig
Congenital Disorder Of Glycosylation Ig	Congenital Disorder Of Glycosylation 1g
Cdg-Ig	Alg12-Cdg
Cdg Syndrome Type Ig	Carbohydrate Deficient Glycoprotein Syndrome Type Ig
Mannosyltransferase 8 Deficiency	Glycosylation, Congenital Disorder Of, Type Ig

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15797	WDR76 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WDR76	RGD	RGD:1309616
Felis catus	WDR76	VGNC	VGNC:67055
Bos taurus	WDR76	VGNC	VGNC:36920
Canis familiaris	WDR76	VGNC	VGNC:48388
Macaca mulatta	WDR76	VGNC	VGNC:79542
Mus musculus	WDR76	MGD	MGI:1926186

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