TRMT2B - tRNA methyltransferase 2 homolog B Gene

Homo sapiens

Also known as CXorf34; dJ341D10.3

Gene ID: 79979 | Gene type: protein coding

About TRMT2B

This gene has 6 transcripts (splice variants), 162 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 3.4), spleen (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Nov 2009]

TRMT2B Products(4)

mRNA	Protein	Name
NM_001167970.2	NP_001161442.1	tRNA (uracil-5-)-methyltransferase homolog B isoform a
NM_001167971.2	NP_001161443.1	tRNA (uracil-5-)-methyltransferase homolog B isoform b
NM_001167972.2	NP_001161444.1	tRNA (uracil-5-)-methyltransferase homolog B isoform a
NM_024917.6	NP_079193.2	tRNA (uracil-5-)-methyltransferase homolog B isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables rRNA (uridine-C5-)-methyltransferase activity	IDA IDA: Inferred from direct assay	31948311	GOA
enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent	IDA IDA: Inferred from direct assay	31948311	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	27184847	GOA
is active in mitochondrion	IDA IDA: Inferred from direct assay	31948311	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT2B Protein Structure

Methyltransf_31

0
100
200
300
400
504 a.a.

Protein Preferred Names

Protein Names

tRNA (uracil-5-)-methyltransferase homolog B

tRNA (uracil(54)-C(5))-methyltransferase homolog

TRM2 homolog

Related Diseases

Diseases

Alias

Loeys-Dietz Syndrome 4

LDS4	Aneurysm, Aortic And Cerebral, With Arterial Tortuosity And Skeletal Manifestations
Loeys-Dietz Syndrome Type 4	Aortic And Cerebral Aneurysm With Arterial Tortuosity And Skeletal Manifestations
Loeys-Dietz Syndrome, Type 4

Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Melas Syndrome	MELAS
Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode
Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes	Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke
Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome
Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15092	TRMT2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRMT2B	VGNC	VGNC:79536
Rattus norvegicus	TRMT2B	RGD	RGD:1565132
Mus musculus	TRMT2B	MGD	MGI:2442530

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