DOCK5 - dedicator of cytokinesis 5 Gene

Homo sapiens

Gene ID: 80005 | Gene type: protein coding

About DOCK5

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:25,184,689-25,415,711 (from NCBI)

This gene has 12 transcripts (splice variants), 222 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 6.2), small intestine (RPKM 5.7) and 25 other tissues.

Summary

This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]

DOCK5 Products(2)

mRNA	Protein	Name
NM_001322810.2	NP_001309739.1	dedicator of cytokinesis protein 5 isoform 2
NM_024940.8	NP_079216.4	dedicator of cytokinesis protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19004829	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of vascular associated smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	22158624	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	19004829	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	19004829	GOA
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	22158624	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	19004829	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOCK5 Protein Structure

SH3_1

DOCK-C2

DHR-2

0
300
600
900
1200
1500
1870 a.a.

Protein Preferred Names

Protein Names

dedicator of cytokinesis protein 5

Related Diseases

Diseases

Alias

Immunodeficiency 40

Dock2 Deficiency	IMD40
Immunodeficiency, Type 40

Li-Fraumeni Syndrome 1

Lfs1

Li-Fraumeni Syndrome 2

LFS2	Li-Fraumeni Syndrome, Type 2
Li-Fraumeni Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110100	CPYPP	Inhibitor	99.94%	Unkown
HY-RS03927	DOCK5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DOCK5	MGD	MGI:2652871
Rattus norvegicus	DOCK5	RGD	RGD:1306872
Bos taurus	DOCK5	VGNC	VGNC:28159
Felis catus	DOCK5	VGNC	VGNC:61574
Macaca mulatta	DOCK5	VGNC	VGNC:83995
Canis familiaris	DOCK5	VGNC	VGNC:40049

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