2. Gene
  3. DOCK5 - dedicator of cytokinesis 5 Gene

DOCK5 - dedicator of cytokinesis 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 80005 | Gene type: protein coding

About DOCK5

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:25,184,689-25,415,711 (from NCBI)

This gene has 12 transcripts (splice variants), 222 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 6.2), small intestine (RPKM 5.7) and 25 other tissues.

Summary

This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]

DOCK5 Products(2)

mRNA Protein Name
NM_001322810.2 NP_001309739.1 dedicator of cytokinesis protein 5 isoform 2
NM_024940.8 NP_079216.4 dedicator of cytokinesis protein 5 isoform 1

DOCK5 Protein Structure

SH3_1

SH3_1: SH3 domain (14 - 60)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (439 - 637)

DHR-2

DHR-2: Dock homology region 2 (1452 - 1634)

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  • 1870 a.a.
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 5

Related Diseases

Diseases Alias
Immunodeficiency 40

Dock2 Deficiency

IMD40

Immunodeficiency, Type 40
Li-Fraumeni Syndrome 1

Lfs1
Li-Fraumeni Syndrome 2

LFS2

Li-Fraumeni Syndrome, Type 2

Li-Fraumeni Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110100 CPYPP Inhibitor 99.94% Unkown
HY-RS03927 DOCK5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DOCK5 MGD MGI:2652871
Rattus norvegicus DOCK5 RGD RGD:1306872
Bos taurus DOCK5 VGNC VGNC:28159
Felis catus DOCK5 VGNC VGNC:61574
Macaca mulatta DOCK5 VGNC VGNC:83995
Canis familiaris DOCK5 VGNC VGNC:40049