BICC1 - BicC family RNA binding protein 1 Gene

Homo sapiens

Also known as BICC; CYSRD

Gene ID: 80114 | Gene type: protein coding

About BICC1

Cytogenetic location: 10q21.1 Genomic coordinates (GRCh38): 10:58,512,220-58,831,435 (from NCBI)

This gene has 3 transcripts (splice variants), 216 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 5.8), gall bladder (RPKM 2.9) and 22 other tissues.

Summary

This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009]

BICC1 Products(1)

mRNA	Protein	Name
NM_001080512.3	NP_001073981.1	protein bicaudal C homolog 1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	21922595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BICC1 Protein Structure

KH_1

SAM_1

0
200
400
600
800
974 a.a.

Protein Preferred Names

Protein Names

protein bicaudal C homolog 1

FGFR2-BICC1 fusion kinase protein

Related Diseases

Diseases

Alias

Renal Dysplasia, Cystic

CYSRD	Renal Dysplasia, Cystic, Susceptibility To
Diffuse Cystic Renal Dysplasia	Renal Dysplasia Diffuse Cystic
Cystic Renal Dysplasia	Susceptibility To Cystic Renal Dysplasia
Dysplasia, Renal, Cystic, Susceptibility To	Multicystic Dysplastic Kidney

Renal Hypodysplasia/Aplasia 1

Renal Agenesis	Renal Adysplasia
Renal Aplasia	RHDA1
Hereditary Renal Aplasia	Hra
Hereditary Urogenital Adysplasia	Hypodysplasia/Aplasia, Renal, Type 1
Congenital Absence Of Kidneys Syndrome	Congenital Absence Of Kidney
Aplastic Kidney

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Spermatogenic Failure 6

Globozoospermia	SPGF6
Round-Headed Spermatozoa	Acrosome Malformation Of Spermatozoa
Spermatogenic Failure 9	Spermatozoa, Round-Headed
Globozoospermia, Complete	Globozoospermia, Total
Mae Infertility Due To Round-Headed Spermatozoa	Male Infertility Due To Globozoospermia
Male Infertility Due To Round-Headed Spermatozoa	Round-Headed Sperm Syndrome
Spgf9	Teratozoospermia

Astigmatism

Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 2	PKD2
Polycystic Kidney Disease, Adult, Type Ii	Apkd2
Polycystic Kidney Disease, Type 2	Adpkd2
Adult Polycystic Kidney Disease Type 2	Autosomal Dominant Polycystic Kidney Disease 2
Pkd-2	Polycystic Kidney Disease Adult Type Ii
Polycystic Kidney Type 2 Autosomal Dominant Disease	Kidney Disease, Polycystic, Type 2

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Intrahepatic Cholangiocarcinoma

Cholangiocarcinoma	Intrahepatic Bile Duct Carcinoma
Peripheral Cholangiocarcinoma	Peripheral Intrahepatic Cholangiocarcinoma
Adenocarcinoma Of Intra-Hepatic Bile Ducts	Cholangiocarcinoma, Unspecified Site
Cholangiocarcinoma Of Liver

Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1	PKD1
Adpkd	Polycystic Kidney Disease, Adult, Type I
Apkd1	Potter Type Iii Polycystic Kidney Disease
Polycystic Kidney Disease, Adult	Potter Type Iii Polycystic Kidney Disease, Formerly
Polycystic Kidney Disease, Type 1	Adpkd1
Adult Polycystic Kidney Disease Type 1	Autosomal Dominant Polycystic Kidney Disease 1
Pkd-1	Polycystic Kidney Disease Adult
Polycystic Kidney Disease Type I	Polycystic Kidneys
Polycystic Kidney Disease, Adult Type I	Polycystic Kidney Type 1 Autosomal Dominant Disease
Kidney Disease, Polycystic, Type 1	Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Type 1 Autosomal Dominant Disease	Polycystic Kidney Diseases

Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

Autosomal Recessive Polycystic Kidney Disease	Arpkd
Polycystic Kidney Disease, Autosomal Recessive	Polycystic Kidney And Hepatic Disease 1
Pkhd1	PKD4
Polycystic Kidney Disease 4 With Or Without Hepatic Disease	Polycystic Kidney Disease, Infantile, Type I
Polycystic Kidney Disease, Infantile Type	Polycystic Kidney, Autosomal Recessive
Pkd3, Formerly	Polycystic Kidney Disease 4, With Or Without Hepatic Disease
Arpkd/Chf	Ar-Pkd
Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease	Infantile Polycystic Kidney Disease Type I
Pkd3	Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease
Polycystic Kidney Disease 3, Autosomal Dominant

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01497	BICC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BICC1	VGNC	VGNC:38449
Mus musculus	BICC1	MGD	MGI:1933388
Felis catus	BICC1	VGNC	VGNC:60111
Bos taurus	BICC1	VGNC	VGNC:26490
Rattus norvegicus	BICC1	RGD	RGD:1307459
Macaca mulatta	BICC1	VGNC	VGNC:70348

Name
Email *

	Sorry, but the email address you supplied was invalid.