2. Gene
  3. VCPIP1 - valosin containing protein interacting protein 1 Gene

VCPIP1 - valosin containing protein interacting protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DUBA3; VCIP135

Gene ID: 80124 | Gene type: protein coding

About VCPIP1

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:66,628,487-66,667,231 (from NCBI)

This gene has 1 transcript (splice variant) and 209 orthologues. Ubiquitous expression in bone marrow (RPKM 10.6), spleen (RPKM 6.5) and 25 other tissues.

Summary

Enables thiol-dependent Deubiquitinase. Involved in protein deubiquitination; protein-DNA covalent cross-linking repair; and regulation of protein localization to chromatin. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

VCPIP1 Products(1)

mRNA Protein Name
NM_025054.5 NP_079330.2 deubiquitinating protein VCPIP1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
23827681 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
32649882 GOA
involved in protein K11-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
involved in protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
32649882 GOA
involved in protein-DNA covalent cross-linking repair IDA
IDA: Inferred from direct assay
32649882 GOA
involved in regulation of protein localization to chromatin IDA
IDA: Inferred from direct assay
32649882 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
32649882 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VCPIP1 Protein Structure

OTU

OTU: OTU-like cysteine protease (215 - 355)

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  • 1222 a.a.
Protein Preferred Names Protein Names

deubiquitinating protein VCPIP1

VCP/p47 complex-interacting 135-kDa protein

Related Diseases

Diseases Alias
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia

Pagetoid Amyotrophic Lateral Sclerosis

Pagetoid Neuroskeletal Syndrome

Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia

Multisystem Proteinopathy

Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone

Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement

Lower Motor Neuron Degeneration With Paget-Like Bone Disease

Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone

Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-158999 VCPIP1-IN-1 99.53% Unkown
HY-159000 VCPIP1-IN-2 Inhibitor ≥98.0% Unkown
HY-RS15624 VCPIP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris VCPIP1 VGNC VGNC:48244
Rattus norvegicus VCPIP1 RGD RGD:708520
Felis catus VCPIP1 VGNC VGNC:66934
Macaca mulatta VCPIP1 VGNC VGNC:79895
Mus musculus VCPIP1 MGD MGI:1917925
Others VCPIP1 NCBI