TRIM46 - tripartite motif containing 46 Gene

Homo sapiens

Also known as GENEY; TRIFIC

Gene ID: 80128 | Gene type: protein coding

About TRIM46

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,173,849-155,184,971 (from NCBI)

This gene has 10 transcripts (splice variants), 271 orthologues and 80 paralogues. Broad expression in brain (RPKM 2.5), testis (RPKM 0.9) and 14 other tissues.

Summary

This gene encodes a protein of the tripartite motif (TRIM) family. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. TRIM46 is reported to be involved in the proliferation of multiple types of Cancer cells including lung and breast Cancer. It has also been shown to control neuronal polarity and axon specification by forming uniform microtubule bundles in the axon. [provided by RefSeq, May 2022]

TRIM46 Products(9)

mRNA	Protein	Name
NM_001256599.2	NP_001243528.1	tripartite motif-containing protein 46 isoform 2
NM_001256601.1	NP_001243530.1	tripartite motif-containing protein 46 isoform 4
NM_001282378.2	NP_001269307.1	tripartite motif-containing protein 46 isoform 5
NM_001282379.2	NP_001269308.1	tripartite motif-containing protein 46 isoform 6
NM_001406245.1	NP_001393174.1	tripartite motif-containing protein 46 isoform 3
NM_001406246.1	NP_001393175.1	tripartite motif-containing protein 46 isoform 7
NM_001406247.1	NP_001393176.1	tripartite motif-containing protein 46 isoform 8
NM_001406256.1	NP_001393185.1	tripartite motif-containing protein 46 isoform 2
NM_025058.5	NP_079334.3	tripartite motif-containing protein 46 isoform 1

TRIM46 Protein Structure

zf-C3HC4

zf-B_box

0
200
400
600
759 a.a.

Protein Preferred Names

Protein Names

tripartite motif-containing protein 46

gene Y protein

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 2

IBD2

Phosphoribosylpyrophosphate Synthetase Superactivity

PRPS1 SUPERACTIVITY	Prpp Synthetase Superactivity
Gout, Prps-Related	Prpp Synthetase Deficiency
Prpp Synthetase Overactivity	Prs Overactivity
Prs Superactivity	Mild Phosphoribosylpyrophosphate Synthetase Superactivity
Mild Prpp Synthetase Superactivity	Mild Prps1 Superactivity
Severe Phosphoribosylpyrophosphate Synthetase Superactivity	Severe Prpp Synthetase Superactivity
Severe Prps1 Superactivity	Prps-Related Gout
Superactivity, Phosphoribosylpyrophosphate Synthetase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15050	TRIM46 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIM46	RGD	RGD:1305993
Bos taurus	TRIM46	VGNC	VGNC:36338
Felis catus	TRIM46	VGNC	VGNC:66542
Mus musculus	TRIM46	MGD	MGI:2673000
Macaca mulatta	TRIM46	VGNC	VGNC:79170
Canis familiaris	TRIM46	VGNC	VGNC:47825

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