PTGES2 - prostaglandin E synthase 2 Gene

Homo sapiens

Also known as GBF1; GBF-1; PGES2; C9orf15; mPGES-2

Gene ID: 80142 | Gene type: protein coding

About PTGES2

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,120,693-128,128,440 (from NCBI)

This gene has 21 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in heart (RPKM 13.3), kidney (RPKM 10.1) and 25 other tissues.

Summary

The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]

PTGES2 Products(3)

mRNA	Protein	Name
NM_001256335.2	NP_001243264.1	prostaglandin E synthase 2 isoform 2
NM_025072.7	NP_079348.1	prostaglandin E synthase 2 isoform 1
NM_198938.3	NP_945176.1	prostaglandin E synthase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lyase activity	IDA IDA: Inferred from direct assay	17585783	GOA
enables prostaglandin-E synthase activity	IDA IDA: Inferred from direct assay	12804604	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lipid metabolic process	IDA IDA: Inferred from direct assay	17585783	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	12835322	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12835322	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGES2 Protein Structure

GST_N_3

GST_C_3

0
100
200
300
377 a.a.

Protein Preferred Names

Protein Names

prostaglandin E synthase 2

GATE-binding factor 1

PTGES2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTGES2	Q9H7Z7	CFAP141	Homo sapiens	Q5VU69	Y2H Prey Pooling	25416956
Intra	PTGES2	Q9H7Z7	CFAP141	Homo sapiens	Q5VU69	Validated Y2H	25416956
Cross	PTGES2	Q9H7Z7	P0DTD1-PRO_0000449625	SARS-CoV-2	P0DTD1-PRO_0000449625	Y2H Array	36217030

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11380	PTGES2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTGES2	VGNC	VGNC:45146
Felis catus	PTGES2	VGNC	VGNC:64428
Macaca mulatta	PTGES2	VGNC	VGNC:76505
Bos taurus	PTGES2	VGNC	VGNC:33506
Rattus norvegicus	PTGES2	RGD	RGD:1310836
Mus musculus	PTGES2	MGD	MGI:1917592

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