MYO19 - myosin XIX Gene

Homo sapiens

Also known as MYOHD1

Gene ID: 80179 | Gene type: protein coding

About MYO19

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:36,495,636-36,544,815 (from NCBI)

This gene has 27 transcripts (splice variants), 1 gene allele, 195 orthologues and 43 paralogues. Ubiquitous expression in skin (RPKM 10.8), esophagus (RPKM 7.0) and 25 other tissues.

Summary

Enables actin binding activity. Involved in regulation of cytokinesis and regulation of mitochondrial fission. Acts upstream of or within mitochondrion migration along actin filament. Located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]

MYO19 Products(3)

mRNA	Protein	Name
NM_001033580.3	NP_001028752.1	unconventional myosin-XIX isoform 3
NM_001163735.2	NP_001157207.1	unconventional myosin-XIX isoform 2
NM_025109.6	NP_079385.2	unconventional myosin-XIX isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	23568824	GOA
enables actin binding	IDA IDA: Inferred from direct assay	23568824	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within mitochondrion migration along actin filament	IDA IDA: Inferred from direct assay	19932026	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	25447992	GOA
involved in regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	25447992	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	27126804	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	23568824	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO19 Protein Structure

Myosin_head

0
200
400
600
800
970 a.a.

Protein Preferred Names

Protein Names

unconventional myosin-XIX

myosin head domain containing 1

Related Diseases

Diseases

Alias

Glycosylphosphatidylinositol Biosynthesis Defect 11

GPIBD11	Hyperphosphatasia With Mental Retardation Syndrome 5
Hpmrs5	Hyperphosphatasia With Mental Retardation Syndrome, Type 5

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08936	MYO19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MYO19	RGD	RGD:1559961
Macaca mulatta	MYO19	VGNC	VGNC:75026
Mus musculus	MYO19	MGD	MGI:1913446
Canis familiaris	MYO19	VGNC	VGNC:43559
Felis catus	MYO19	VGNC	VGNC:63686
Bos taurus	MYO19	VGNC	VGNC:31815

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