TRIM45 - tripartite motif containing 45 Gene

Homo sapiens

Also known as RNF99

Gene ID: 80263 | Gene type: protein coding

About TRIM45

Cytogenetic location: 1p13.1 Genomic coordinates (GRCh38): 1:117,111,060-117,123,927 (from NCBI)

This gene has 5 transcripts (splice variants), 185 orthologues and 80 paralogues. Ubiquitous expression in endometrium (RPKM 2.4), thyroid (RPKM 2.2) and 24 other tissues.

Summary

This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]

TRIM45 Products(2)

mRNA	Protein	Name
NM_001145635.2	NP_001139107.1	tripartite motif-containing protein 45 isoform 2
NM_025188.4	NP_079464.2	tripartite motif-containing protein 45 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	28542145	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	36681779	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	36681779	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	36681779	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	36681779	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM45 Protein Structure

zf-C3HC4

zf-B_box

Filamin

0
100
200
300
400
500
580 a.a.

Protein Preferred Names

Protein Names

tripartite motif-containing protein 45

ring finger protein 99

Related Diseases

Diseases

Alias

Erythematosquamous Dermatosis

Other Erythematosquamous Dermatosis

Birdshot Chorioretinopathy

Birdshot Chorioretinitis	Bscr
Birdshot Retinochoroiditis	Birdshot Retinochoroidopathy
Vitiliginous Choroiditis	Multiple Small, Cream-Colored Lesions, Symmetrically Scattered Mainly Around The Optic Disk

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15049	TRIM45 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRIM45	VGNC	VGNC:79169
Felis catus	TRIM45	VGNC	VGNC:66541
Bos taurus	TRIM45	VGNC	VGNC:36337
Mus musculus	TRIM45	MGD	MGI:1918187
Canis familiaris	TRIM45	VGNC	VGNC:47824
Rattus norvegicus	TRIM45	RGD	RGD:1309168

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