WDR82 - WD repeat domain 82 Gene

Homo sapiens

Also known as SWD2; MST107; WDR82A; MSTP107; PRO2730; TMEM113; PRO34047

Gene ID: 80335 | Gene type: protein coding

About WDR82

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:52,254,434-52,278,649 (from NCBI)

This gene has 4 transcripts (splice variants) and 271 orthologues. Ubiquitous expression in brain (RPKM 35.2), endometrium (RPKM 34.7) and 25 other tissues.

Summary

TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]

WDR82 Products(1)

mRNA	Protein	Name
NM_025222.4	NP_079498.2	WD repeat-containing protein 82

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17998332	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lncRNA catabolic process	IDA IDA: Inferred from direct assay	33913806	GOA
involved in negative regulation of DNA-templated transcription, elongation	IDA IDA: Inferred from direct assay	33913806	GOA
involved in negative regulation of lncRNA transcription	IDA IDA: Inferred from direct assay	33913806	GOA
involved in nuclear RNA surveillance	IDA IDA: Inferred from direct assay	33913806	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PTW/PP1 phosphatase complex	IDA IDA: Inferred from direct assay	20516061	GOA
part of Set1C/COMPASS complex	IDA IDA: Inferred from direct assay	17998332	GOA
part of Set1C/COMPASS complex	IPI IPI: Inferred from physical interaction	23508102	GOA
located in chromatin	IDA IDA: Inferred from direct assay	20516061	GOA
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	24270157	GOA
part of histone methyltransferase complex	IDA IDA: Inferred from direct assay	17355966	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR82 Protein Structure

WD40

0
100
200
313 a.a.

Protein Preferred Names

Protein Names

WD repeat-containing protein 82

transmembrane protein 113

Related Diseases

Diseases

Alias

Kleefstra Syndrome 2

KLEFS2

Kleefstra Syndrome, Type 2

Kabuki Syndrome 1

Kabuki Syndrome	Niikawa-Kuroki Syndrome
Kabuki Make-Up Syndrome	Kms
KABUK1	Kabuki Make Up Syndrome
Nks	Kabuki Makeup Syndrome
Kabuki Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS15800	WDR82 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WDR82	RGD	RGD:1584269
Mus musculus	WDR82	MGD	MGI:1924555
Canis familiaris	WDR82	VGNC	VGNC:48391
Macaca mulatta	WDR82	VGNC	VGNC:82558
Bos taurus	WDR82	VGNC	VGNC:107026
Felis catus	WDR82	VGNC	VGNC:67059

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