PRR7 - proline rich 7, synaptic Gene

Homo sapiens

Gene ID: 80758 | Gene type: protein coding

About PRR7

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,445,995-177,456,286 (from NCBI)

This gene has 4 transcripts (splice variants), 122 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 2.0), brain (RPKM 0.9) and 12 other tissues.

Summary

Enables long-chain fatty acid binding activity; protein tyrosine kinase binding activity; and ubiquitin-like protein Ligase binding activity. Involved in negative regulation of protein ubiquitination; positive regulation of apoptotic process; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PRR7 Products(5)

mRNA	Protein	Name
NM_001174101.2	NP_001167572.1	proline-rich protein 7
NM_001174102.3	NP_001167573.1	proline-rich protein 7
NM_001375593.1	NP_001362522.1	proline-rich protein 7
NM_001375594.1	NP_001362523.1	proline-rich protein 7
NM_030567.5	NP_085044.2	proline-rich protein 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables long-chain fatty acid binding	IMP IMP: Inferred from mutant phenotype	21460222	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27458189	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	21460222	GOA
enables ubiquitin-like protein ligase binding	IPI IPI: Inferred from physical interaction	27458189	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21460222	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21460222	GOA
involved in regulation of transcription by RNA polymerase I	IMP IMP: Inferred from mutant phenotype	27458189	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IMP IMP: Inferred from mutant phenotype	21460222	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	21460222	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRR7 Protein Structure

WBP-1

0
100
200
274 a.a.

Protein Preferred Names

Protein Names

proline-rich protein 7

synaptic proline-rich membrane protein

Related Diseases

Diseases

Alias

Mitochondrial Complex Ii Deficiency

Isolated Mitochondrial Respiratory Chain Complex Ii Deficiency	Isolated Succinate-Coenzyme Q Reductase Deficiency
Isolated Succinate-Coq Reductase Deficiency	Isolated Succinate-Ubiquinone Reductase Deficiency
Mitochondrial Respiratory Chain Complex Ii Deficiency	Complex 2 Mitochondrial Respiratory Chain Deficiency
Succinate Coq Reductase Deficiency	Succinate Dehydrogenase Deficiency
Isolated Succinate Dehydrogenase Deficiency	Succinate-Coenzyme Q Reductase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11233	PRR7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PRR7	VGNC	VGNC:110441
Canis familiaris	PRR7	VGNC	VGNC:45049
Mus musculus	PRR7	MGD	MGI:3487246
Felis catus	PRR7	VGNC	VGNC:102296
Rattus norvegicus	PRR7	RGD	RGD:1561898
Bos taurus	PRR7	VGNC	VGNC:33402

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