CPTP - ceramide-1-phosphate transfer protein Gene

Homo sapiens

Also known as GLTPD1

Gene ID: 80772 | Gene type: protein coding

About CPTP

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,324,802-1,328,896 (from NCBI)

This gene has 3 transcripts (splice variants), 338 orthologues and 5 paralogues. Broad expression in testis (RPKM 11.0), colon (RPKM 8.1) and 25 other tissues.

Summary

Enables ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Involved in several processes, including ceramide 1-phosphate transport; negative regulation of NLRP3 inflammasome complex assembly; and negative regulation of interleukin-1 beta production. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CPTP Products(1)

mRNA	Protein	Name
NM_001029885.2	NP_001025056.1	ceramide-1-phosphate transfer protein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ceramide 1-phosphate binding	IDA IDA: Inferred from direct assay	23863933	GOA
enables ceramide 1-phosphate transfer activity	IDA IDA: Inferred from direct assay	23863933	GOA
enables phospholipid binding	IDA IDA: Inferred from direct assay	23863933	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ceramide 1-phosphate transport	IDA IDA: Inferred from direct assay	23863933	GOA
NOT involved in glycolipid transport	IDA IDA: Inferred from direct assay	23863933	GOA
involved in negative regulation of NLRP3 inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	29164996	GOA
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	29164996	GOA
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	29164996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPTP Protein Structure

GLTP

0
100
200
214 a.a.

Protein Preferred Names

Protein Names

ceramide-1-phosphate transfer protein

GLTP domain-containing protein 1

Related Diseases

Diseases

Alias

Axenfeld-Rieger Syndrome, Type 1

Axenfeld-Rieger Syndrome Type 1	RIEG1
Rieg	Rgs
Rieger Syndrome Type 1	Rieger Syndrome, Type 1
Axenfeld-Rieger Syndrome 1	Iridogoniodysgenesis With Somatic Anomalies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03126	CPTP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CPTP	MGD	MGI:1933107
Bos taurus	CPTP	VGNC	VGNC:27680
Felis catus	CPTP	VGNC	VGNC:107518
Macaca mulatta	CPTP	VGNC	VGNC:71599
Canis familiaris	CPTP	VGNC	VGNC:39583
Rattus norvegicus	CPTP	RGD	RGD:1359656
Others	CPTP	NCBI

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