CALM3 - calmodulin 3 Gene

Homo sapiens

Also known as CaM; CALM; CAM1; CAM2; CAMB; PHKD; CPVT6; LQT16; PHKD3; CaMIII; HEL-S-72

Gene ID: 808 | Gene type: protein coding

About CALM3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,601,074-46,610,782 (from NCBI)

This gene has 13 transcripts (splice variants), 195 orthologues, 20 paralogues and is associated with 5 phenotypes. Ubiquitous expression in brain (RPKM 470.4), testis (RPKM 108.1) and 23 other tissues.

Summary

This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]

CALM3 Products(7)

mRNA	Protein	Name
NM_001329921.1	NP_001316850.1	calmodulin-3 isoform 2
NM_001329922.1	NP_001316851.1	calmodulin-3 isoform 1
NM_001329923.1	NP_001316852.1	calmodulin-3 isoform 2
NM_001329924.2	NP_001316853.1	calmodulin-3 isoform 2
NM_001329925.2	NP_001316854.1	calmodulin-3 isoform 2
NM_001329926.2	NP_001316855.1	calmodulin-3 isoform 2
NM_005184.4	NP_005175.2	calmodulin-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenylate cyclase activator activity	IDA IDA: Inferred from direct assay	11807546	GOA
enables adenylate cyclase binding	IPI IPI: Inferred from physical interaction	11807546	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	7607248	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	3111527	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20668654	GOA
enables protein phosphatase activator activity	IDA IDA: Inferred from direct assay	8631777	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	35568036	GOA
enables titin binding	IPI IPI: Inferred from physical interaction	7607248	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	21167176	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in detection of calcium ion	IMP IMP: Inferred from mutant phenotype	23040497	GOA
involved in negative regulation of high voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	31454269	GOA
involved in positive regulation of cyclic-nucleotide phosphodiesterase activity	IDA IDA: Inferred from direct assay	8631777	GOA
involved in positive regulation of ryanodine-sensitive calcium-release channel activity	IDA IDA: Inferred from direct assay	20226167	GOA
involved in regulation of cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	31454269	GOA
involved in regulation of cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	23040497	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	16760425	GOA
involved in regulation of heart rate	IMP IMP: Inferred from mutant phenotype	23040497	GOA
involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	20226167	GOA
involved in response to calcium ion	IDA IDA: Inferred from direct assay	7607248	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of calcium channel complex	IDA IDA: Inferred from direct assay	23040497	GOA
part of catalytic complex	IDA IDA: Inferred from direct assay	11807546	GOA
located in centrosome	IDA IDA: Inferred from direct assay	16760425	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	19855925	GOA
located in sarcomere	IDA IDA: Inferred from direct assay	20226167	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	16760425	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	16760425	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALM3 Protein Structure

EF-hand_7

0
100
149 a.a.

Protein Preferred Names

Protein Names

calmodulin-3

Calmodulin-1

Recombinant CALM3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7710	Calmodulin Protein, Human	P0DP23 (M1-K149)	≥95%
HY-P75461	CALM2 Protein, Human (His)	P0DP24 (M1-K149)	≥95%

CALM3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82082	Calmodulin Antibody (YA1827)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Long Qt Syndrome 16

Ventricular Tachycardia, Catecholaminergic Polymorphic, 6	LQT16
Ventricular Tachycardia, Catecholaminergic Polymorphic 6	CPVT6

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Catecholaminergic Polymorphic Ventricular Tachycardia

Cpvt	Catecholamine-Induced Polymorphic Ventricular Tachycardia
Familial Polymorphic Ventricular Tachycardia	Malignant Paroxysmal Ventricular Tachycardia
Multifocal Ventricular Premature Beats	Stress-Induced Polymorphic Ventricular Tachycardia
Bidirectional Tachycardia Induced By Catecholamine	Double Tachycardia Induced By Catecholamines
Polymorphic Catecholergic Ventricular Tachycardia	Syncopal Paroxysmal Tachycardia
Bidirectional Tachycardia Induced By Catecholamines	Fpvt
Bidirectional Ventricular Tachycardia Induced By Catecholamine	Polymorphic Ventricular Tachycardia Induced By Catecholamines
Ventricular Tachycardia, Catecholaminergic Polymorphic	Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
Familial Ventricular Tachycardia	Multifocal Pvcs
Multifocal Premature Ventricular Beats

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Long Qt Syndrome 14

LQT14

Long Qt Syndrome, Type 14

Long Qt Syndrome 15

LQT15

Long Qt Syndrome, Type 15

Cardiac Arrest

Cardiopulmonary Arrest	Circulatory Arrest
Heart Arrest

Flying Phobia

Aerophobia

Medulloblastoma Shh Activated And Tp53 Mutant

Diamond-Blackfan Anemia 3

DBA3	Anemia, Diamond-Blackfan, 3
Rps24-Related Diamond-Blackfan Anemia	Anemia Diamond-Blackfan 3
Anemia, Diamond-Blackfan, Type 3

Medulloblastoma Non-Wnt/Non-Shh

Long Qt Syndrome 2

LQT2	Long Qt Syndrome, Acquired, Reduced Susceptibility To
Long Qt Syndrome 1/2	Long Qt Syndrome 2/3
Long Qt Syndrome 2/5	Long Qt Syndrome 2, Acquired, Susceptibility To
Long Qt Syndrome, Acquired, Reduced	Long Qt Syndrome Type 2
Long Qt Syndrome 2/9	Lqt1/2
Lqt2/3	Lqt2/5
Lqt2/9	Susceptibility To Acquired Long Qt Syndrome 2
Long Qt Syndrome-2	Qt Syndrome, Long, Type 2
Long Qt Syndrome 1-2	Long Qt Syndrome 2-3
Long Qt Syndrome 2-5	Long Qt Syndrome 9

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01842	CALM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CALM3	MGD	MGI:103249
Rattus norvegicus	CALM3	RGD	RGD:2259

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