TAS1R2 - taste 1 receptor member 2 Gene

Homo sapiens

Also known as TR2; T1R2; GPR71

Gene ID: 80834 | Gene type: protein coding

About TAS1R2

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:18,839,599-18,859,660 (from NCBI)

This gene has 1 transcript (splice variant), 359 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

Contributes to sweet Taste Receptor activity. Involved in detection of chemical stimulus involved in sensory perception of sweet taste and positive regulation of cytokinesis. Part of sweet Taste Receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

TAS1R2 Products(1)

mRNA	Protein	Name
NM_152232.6	NP_689418.2	taste receptor type 1 member 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to sweet taste receptor activity	IDA IDA: Inferred from direct assay	16720576	GOA
contributes to taste receptor activity	IDA IDA: Inferred from direct assay	16720576	GOA
enables taste receptor activity	IPI IPI: Inferred from physical interaction	11917125	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in detection of chemical stimulus involved in sensory perception of sweet taste	IDA IDA: Inferred from direct assay	16720576	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	22888021	GOA
involved in sensory perception of sweet taste	IDA IDA: Inferred from direct assay	11917125	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA
part of sweet taste receptor complex	IDA IDA: Inferred from direct assay	16720576	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAS1R2 Protein Structure

ANF_receptor

NCD3G

7tm_3

0
200
400
600
839 a.a.

Protein Preferred Names

Protein Names

taste receptor type 1 member 2

G-protein coupled receptor 71

Related Diseases

Diseases

Alias

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Renal Pelvis Transitional Cell Carcinoma

Urothelial Cell Carcinoma Of Renal Pelvis	Renal Pelvis Urothelial Carcinoma
Transitional Cell Carcinoma Of Renal Pelvis

Glucocorticoid Deficiency 1

Acth Resistance	Glucocorticoid Deficiency, Due To Acth Unresponsiveness
GCCD1	Familial Glucocorticoid Deficiency 1
Fgd1	Adrenal Unresponsiveness To Acth
Hereditary Unresponsiveness To Adrenocorticotropic Hormone	Isolated Glucocorticoid Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2084	Perillartine		99.80%	Unkown
HY-RS14213	TAS1R2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TAS1R2	VGNC	VGNC:35608
Macaca mulatta	TAS1R2	VGNC	VGNC:100154
Rattus norvegicus	TAS1R2	RGD	RGD:61894
Mus musculus	TAS1R2	MGD	MGI:1933546

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