TAS1R1 - taste 1 receptor member 1 Gene

Homo sapiens

Also known as TR1; T1R1; GM148; GPR70

Gene ID: 80835 | Gene type: protein coding

About TAS1R1

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,555,307-6,579,755 (from NCBI)

This gene has 4 transcripts (splice variants), 111 orthologues and 4 paralogues. Biased expression in testis (RPKM 1.2), gall bladder (RPKM 0.1) and 7 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid Taste Receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most Amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

TAS1R1 Products(2)

mRNA	Protein	Name
NM_138697.4	NP_619642.2	taste receptor type 1 member 1 isoform b precursor
NM_177540.3	NP_803884.1	taste receptor type 1 member 1 isoform c precursor

TAS1R1 Protein Structure

ANF_receptor

NCD3G

7tm_3

0
200
400
600
841 a.a.

Protein Preferred Names

Protein Names

taste receptor type 1 member 1

G-protein coupled receptor 70

Related Diseases

Diseases

Alias

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Glucocorticoid Deficiency 1

Acth Resistance	Glucocorticoid Deficiency, Due To Acth Unresponsiveness
GCCD1	Familial Glucocorticoid Deficiency 1
Fgd1	Adrenal Unresponsiveness To Acth
Hereditary Unresponsiveness To Adrenocorticotropic Hormone	Isolated Glucocorticoid Deficiency

Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1	PKD1
Adpkd	Polycystic Kidney Disease, Adult, Type I
Apkd1	Potter Type Iii Polycystic Kidney Disease
Polycystic Kidney Disease, Adult	Potter Type Iii Polycystic Kidney Disease, Formerly
Polycystic Kidney Disease, Type 1	Adpkd1
Adult Polycystic Kidney Disease Type 1	Autosomal Dominant Polycystic Kidney Disease 1
Pkd-1	Polycystic Kidney Disease Adult
Polycystic Kidney Disease Type I	Polycystic Kidneys
Polycystic Kidney Disease, Adult Type I	Polycystic Kidney Type 1 Autosomal Dominant Disease
Kidney Disease, Polycystic, Type 1	Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Type 1 Autosomal Dominant Disease	Polycystic Kidney Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14212	TAS1R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TAS1R1	VGNC	VGNC:35607
Mus musculus	TAS1R1	MGD	MGI:1927505
Macaca mulatta	TAS1R1	VGNC	VGNC:78115
Canis familiaris	TAS1R1	VGNC	VGNC:47112
Felis catus	TAS1R1	VGNC	VGNC:65958
Rattus norvegicus	TAS1R1	RGD	RGD:61891

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