SLC2A10 - solute carrier family 2 member 10 Gene

Homo sapiens

Also known as ATS; ATORS; GLUT10

Gene ID: 81031 | Gene type: protein coding

About SLC2A10

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:46,708,320-46,736,347 (from NCBI)

This gene has 3 transcripts (splice variants), 281 orthologues, 13 paralogues and is associated with 3 phenotypes. Broad expression in prostate (RPKM 8.3), thyroid (RPKM 6.7) and 24 other tissues.

Summary

This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]

SLC2A10 Products(1)

mRNA	Protein	Name
NM_030777.4	NP_110404.1	solute carrier family 2, facilitated glucose transporter member 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	11592815	GOA
enables dehydroascorbic acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	27153185	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-glucose import across plasma membrane	IDA IDA: Inferred from direct assay	11592815	GOA
acts upstream of or within artery development	IMP IMP: Inferred from mutant phenotype	16550171	GOA
acts upstream of or within cell redox homeostasis	IMP IMP: Inferred from mutant phenotype	26376865	GOA
involved in dehydroascorbic acid transport	IDA IDA: Inferred from direct assay	27153185	GOA
acts upstream of or within embryonic skeletal joint development	IMP IMP: Inferred from mutant phenotype	18565096	GOA
acts upstream of or within negative regulation of connective tissue growth factor production	IMP IMP: Inferred from mutant phenotype	16550171	GOA
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16550171	GOA
acts upstream of negative regulation of integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	26376865	GOA
acts upstream of or within negative regulation of proteoglycan biosynthetic process	IMP IMP: Inferred from mutant phenotype	16550171	GOA
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16550171	GOA
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16550171	GOA
acts upstream of or within positive regulation of proteoglycan biosynthetic process	IMP IMP: Inferred from mutant phenotype	16550171	GOA
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26376865	GOA
acts upstream of or within regulation of extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	26376865	GOA
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	18565096	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16550171	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	11592815	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC2A10 Protein Structure

Sugar_tr

0
100
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300
400
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541 a.a.

Protein Preferred Names

Protein Names

solute carrier family 2, facilitated glucose transporter member 10

GLUT-10

Related Diseases

Diseases

Alias

Arterial Tortuosity Syndrome

Arterial Tortuosity	Ats
ATORS	Tortuosity, Arterial, Syndrome

Aortic Aneurysm, Familial Thoracic 4

AAT4	Faa4
Aortic Aneurysm/Aortic Dissection And Patent Ductus Arteriosus	Familial Aortic Aneurysm 4
Non-Syndromic Thoracic Aortic Aneurysms And Dissection	Taad
Thoracic Aortic Aneurysms And Dissection	Thoracic Aortic Aneurysms And Dissections
Aneurysm, Aortic, Thoracic, Familial, Type 4

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Cutis Laxa, Autosomal Dominant 1

Cutis Laxa, Autosomal Dominant	Autosomal Dominant Cutis Laxa
ADCL1	Adcl
Autosomal Dominant Cutis Laxa 1	Cutis Laxa, Autosomal Dominant, 1
Cutis Laxa, Autosomal Dominant, Type 1

Tricuspid Valve Prolapse

Regular Astigmatism

Loeys-Dietz Syndrome 3

LDS3	Aneurysms-Osteoarthritis Syndrome
Loeys-Dietz Syndrome With Osteoarthritis	Aneurysm-Osteoarthritis Syndrome
Lds1c	Loeys-Dietz Syndrome, Type 3
Loeys-Dietz Syndrome, Type 1c, Formerly	Lds1c, Formerly
Loeys-Dietz Syndrome Type 1c	Loeys-Dietz Syndrome Type 3
Aneurysm - Osteoarthritis Syndrome	Loeys-Dietz Syndrome, Type 1c
Aos	Loeys-Dietz Syndrome 1c

Loeys-Dietz Syndrome

Loeys-Dietz Aortic Aneurysm Syndrome	Lds
Aortic Aneurysm Syndrome Due To Tgf-Beta Receptors Anomalies	Furlong Syndrome

Aortic Aneurysm

Aortic Rupture	Thoracoabdominal Aortic Aneurysm, Ruptured
Ruptured Aortic Aneurysm	Aortic Aneurysms
Aortic Aneurysm Without Mention Of Rupture Nos	Ruptured Abdominal Aortic Aneurysm
Aortic Aneurysm, Ruptured	Ruptured Thoracic Aortic Aneurysm

Cutis Laxa, Autosomal Recessive, Type Ib

ARCL1B	Cutis Laxa, Autosomal Recessive, Type 1b
Autosomal Recessive Cutis Laxa Type Ib	Lethal Arteriopathy Syndrome Due To Fibulin-4 Deficiency
Cutis Laxa, Autosomal Recessive, 1b	Cutis Laxa Autosomal Recessive Type Ib

Cutis Laxa, Autosomal Recessive, Type Iib

ARCL2B	Cutis Laxa With Progeroid Features
Autosomal Recessive Cutis Laxa Type 2b	Autosomal Recessive Cutis Laxa Type Iib
Arcl2, Progeroid Type	Cutis Laxa, Autosomal Recessive Type 2b
Autosomal Recessive Cutis Laxa Type 2, Progeroid Type	Cutis Laxa, Autosomal Recessive, 2b
Cl Type Iib	Cutis Laxa Autosomal Recessive Type Iib
Cutis Laxa, Autosomal Recessive, Type 2b

Progressive Pseudorheumatoid Dysplasia

Progressive Pseudorheumatoid Arthropathy Of Childhood	Arthropathy, Progressive Pseudorheumatoid, Of Childhood
Spondyloepiphyseal Dysplasia Tarda With Progressive Arthropathy	Ppd
Ppac	Sedt-Pa
Spondyloepiphyseal Dysplasia Tarda-Progressive Arthropathy Syndrome	PPRD
Progressive Pseudorheumatoid Chondrodysplasia	Spondyloepiphyseal Dysplasia Tarda - Progressive Arthropathy
Spondyloepiphyseal Dysplasia Tarda With Progressive Arthropathy
Dysplasia, Pseudorheumatoid, Progressive

Autosomal Recessive Cutis Laxa Type I

Autosomal Recessive Cutis Laxa Type 1	Cutis Laxa, Type 1
Cutis Laxa, Autosomal Recessive, Type I	Cutis Laxa, Autosomal Recessive Type 1
Cutis Laxa, Autosomal Recessive	Arcl1
Autosomal Recessive Cutis Laxa With Severe Systemic Involvement	Autosomal Recessive Cutis Laxa, Pulmonary Emphysema Type

Meester-Loeys Syndrome

MRLS

Bladder Diverticulum

Diverticulum Of Bladder	Diverticulum - Bladder
Bladder Diverticula	Vesical Diverticulum
Bladder Sacculation

Aortic Dissection

Contractural Arachnodactyly, Congenital

Congenital Contractural Arachnodactyly	Beals Syndrome
CCA	Beals-Hecht Syndrome
Distal Arthrogryposis Type 9	Arthrogryposis, Distal, Type 9
Da9	Arachnodactyly, Contractural Beals Type
Contractures, Multiple With Arachnodactyly	Ear Anomalies-Contractures-Dysplasia Of Bone With Kyphoscoliosis
Arthrogyroposis, Distal, Type 9	Distal Arthrogyropsis Type 9
Cca Syndrome	Arachnodactyly

Loeys-Dietz Syndrome 4

LDS4	Aneurysm, Aortic And Cerebral, With Arterial Tortuosity And Skeletal Manifestations
Loeys-Dietz Syndrome Type 4	Aortic And Cerebral Aneurysm With Arterial Tortuosity And Skeletal Manifestations
Loeys-Dietz Syndrome, Type 4

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Inguinal Hernia

Hernia Inguinal	Hernia, Inguinal
Inguinal Hernias	Bubonocele
Indirect Inguinal Hernia	Direct Inguinal Hernia
Oblique Inguinal Hernia	Scrotal Hernia
Ih - [Inguinal Hernia]

Collagen Disease

Collagen Diseases

Collagen Disorder

Cutis Laxa

Generalized Elastolysis	Loose Skin
Dermatolysis	Dermatomegaly
Cutis Laxa Syndrome

Orthostatic Intolerance

Mitral Valve Prolapse	Neurocirculatory Asthenia
Mitral Valve Prolapse Syndrome	Irritable Heart
Systolic Click-Murmur Syndrome	Soldiers Heart
Cardiovascular Malfunction Arising From Mental Factors	Cardiovascular Neurosis
Da Costa'S Syndrome	Krishaber'S Disease
Barlow'S Syndrome	Floppy Mitral Valve
Mitral Leaflet Syndrome	Myxomatous Mitral Valve Prolapse
Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency	Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency
Orthostatic Intolerance Due To Net Deficiency	Pots Due To Net Deficiency
OI	Intolerance, Orthostatic
Mitral Valve Prolapse, Familial, X-Linked	Ballooning Mitral Valve
Barlow Syndrome	Flail Mitral Leaflet
Myxomatous Mitral Valve	Mitral Valve Prolapse-Click Syndrome
Prolapsing Mitral Valve Leaflet Syndrome	Billowing Mitral Valve Leaflet
Posterior Mitral Leaflet Deformity	Ballooning Posterior Leaflet Syndrome
Blue Valve Syndrome	Floppy Mitral Valve Syndrome
Mitral Valvular Prolapse	Systolic Click Syndrome

Ehlers-Danlos Syndrome

Eds	Cutis Hyperelastica
Elastic Skin	Ehlers-Danlos Syndromes
Ed Syndrome	Ehlers Danlos Syndrome
Ehlers Danlos Disease	Eds - [Ehlers-Danlos Syndrome]

Moyamoya Disease 1

Moyamoya Disease	Spontaneous Occlusion Of The Circle Of Willis
Mymy	Progressive Intracranial Arterial Occlusion
Moyamoya Syndrome	MYMY1
Cerebrovascular Moyamoya Disease	Moya-Moya Disease
Progressive Intracranial Occlusive Arteropathy	Idiopathic Moyamoya Disease

Patent Ductus Arteriosus 1

Patent Ductus Arteriosus	PDA1
Pda	Ductus Arteriosus, Patent
Patent Ductus Arteriosus, Susceptibility To	Patent Ductus Botalli
Patency Of The Ductus Arteriosus	Patent Ductus Arteriosus Familial
Ductus Arteriosus Patent	Patent Ductus Arteriosus - Persisting Type

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia	Diaphragmatic Hernia
Cdh	Congenital Diaphragmatic Defect
Hernia, Diaphragmatic	Dih
Hernia, Congenital Diaphragmatic	Hcd
Diaphragmatic Defect, Congenital	Diaphragm, Unilateral Agenesis Of
Hemidiaphragm, Agenesis Of	Diaphragmatic Hernia 1
Agenesis Of Hemidiaphragm	Unilateral Agenesis Of Diaphragm
Hernia Diaphragmatic	Hernia Diaphragmatic Congenital
Hernia, Diaphragmatic, Type 1	Hiatus Hernia
Oesophageal Hiatus Hernia	Paraoesophageal Hernia
Sliding Hiatus Hernia	Congenital Diaphragm Hernia
Congenital Diaphragm Defect With Hernia	Gross Congenital Diaphragm Defect

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13160	SLC2A10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC2A10	RGD	RGD:1306552
Canis familiaris	SLC2A10	VGNC	VGNC:46338
Mus musculus	SLC2A10	MGD	MGI:2156687
Bos taurus	SLC2A10	VGNC	VGNC:34797
Macaca mulatta	SLC2A10	VGNC	VGNC:77465
Felis catus	SLC2A10	VGNC	VGNC:65300

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