OR51E2 - olfactory receptor family 51 subfamily E member 2 Gene

Homo sapiens

Also known as PSGR; HPRAJ; OR52A2; OR51E3P

Gene ID: 81285 | Gene type: protein coding

About OR51E2

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:4,680,171-4,697,853 (from NCBI)

This gene has 3 transcripts (splice variants), 108 orthologues and 51 paralogues. Biased expression in prostate (RPKM 29.8) and placenta (RPKM 2.3).

Summary

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory Receptor Proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of Other organisms. [provided by RefSeq, Jul 2008]

OR51E2 Products(1)

mRNA	Protein	Name
NM_030774.4	NP_110401.1	olfactory receptor 5.10E+03

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear steroid receptor activity	IDA IDA: Inferred from direct assay	19389702	GOA
enables olfactory receptor activity	IDA IDA: Inferred from direct assay	19389702	GOA
enables olfactory receptor activity	IMP IMP: Inferred from mutant phenotype	29249973	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	29249973	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	29249973	GOA
involved in melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	27226631	GOA
involved in melanocyte proliferation	IMP IMP: Inferred from mutant phenotype	27226631	GOA
involved in steroid hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	19389702	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome membrane	IDA IDA: Inferred from direct assay	27226631	GOA
located in intracellular organelle	IDA IDA: Inferred from direct assay	29249973	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23401498	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OR51E2 Protein Structure

7tm_4

0
100
200
300
320 a.a.

Protein Preferred Names

Protein Names

olfactory receptor 51E2

olfactory receptor OR11-16

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS09818	OR51E2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	OR51E2	VGNC	VGNC:101075
Rattus norvegicus	OR51E2	RGD	RGD:628858
Canis familiaris	OR51E2	VGNC	VGNC:97040
Mus musculus	OR51E2	MGD	MGI:2157548

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