DCSTAMP - dendrocyte expressed seven transmembrane protein Gene

Homo sapiens

Also known as FIND; TM7SF4; hDC-STAMP

Gene ID: 81501 | Gene type: protein coding

About DCSTAMP

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:104,339,796-104,356,689 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues and 3 paralogues. Biased expression in lung (RPKM 1.3), liver (RPKM 0.2) and 4 other tissues.

Summary

This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

DCSTAMP Products(2)

mRNA	Protein	Name
NM_001257317.1	NP_001244246.1	dendritic cell-specific transmembrane protein isoform 2
NM_030788.4	NP_110415.1	dendritic cell-specific transmembrane protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20546900	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to interleukin-4	IDA IDA: Inferred from direct assay	15601667	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	11169400	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	15601667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCSTAMP Protein Structure

DC_STAMP

0
100
200
300
400
470 a.a.

Protein Preferred Names

Protein Names

dendritic cell-specific transmembrane protein

DC-specific transmembrane protein

DCSTAMP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DCSTAMP	Q9H295	CREB3	Homo sapiens	O43889-2	Y2H	20546900
Intra	DCSTAMP	Q9H295	CREB3	Homo sapiens	O43889-2	Confocal	20546900

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mammary Paget'S Disease

Paget'S Disease	Mammary Paget Disease
Paget'S Disease Of The Breast	Paget Disease Of The Breast
Paget'S Disease Of The Nipple	Paget'S Disease, Mammary
Paget Cell Neoplasm	Paget Disease Of The Nipple
Pagets Disease Mammary	Osteitis Deformans

Paget'S Disease Of Bone

Osteitis Deformans	Paget Disease Of Bone
Osseous Paget'S Disease	Paget Disease Of Bone, Familial
Bone Paget Disease	Familial Paget'S Disease Of Bone
Paget'S Bone Disease	Familial Paget Disease Of Bone
Paget Disease, Bone	Pdb
Pagets Bone Disease

Bone Remodeling Disease

Osteopetrosis

Marble Bone Disease	Albers-Schonberg Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

Bone Resorption Disease

Bone Resorption

Ischemic Bone Disease

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03590	DCSTAMP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DCSTAMP	VGNC	VGNC:81645
Macaca mulatta	DCSTAMP	VGNC	VGNC:71659
Rattus norvegicus	DCSTAMP	RGD	RGD:1310435
Bos taurus	DCSTAMP	VGNC	VGNC:27925
Canis familiaris	DCSTAMP	VGNC	VGNC:49724
Mus musculus	DCSTAMP	MGD	MGI:1923016

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