Bdkrb1 - bradykinin receptor B1 Gene

Rattus norvegicus

Also known as BKR; Bdkrb; b1bkr

Gene ID: 81509 | Gene type: protein coding

About Bdkrb1

Primary_assembly 6: 124,510,870-124,513,747 forward strand.mRatBN7.2:CM026979.1

This gene has 1 transcript (splice variant), 147 orthologues, 8 paralogues and is associated with 34 phenotypes. Biased expression in Uterus (RPKM 5.6), Adrenal (RPKM 1.6) and 3 other tissues.

Summary

Enables Bradykinin Receptor activity and peptide binding activity. Involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; protein kinase C-activating G protein-coupled receptor signaling pathway; and response to lipopolysaccharide. Located in neuron projection and plasma membrane. Used to study diabetic angiopathy; epilepsy; hypertension; neuropathy (multiple); and pleurisy. Biomarker of diabetic retinopathy; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in end stage renal disease; hypertension; and pulmonary fibrosis. Orthologous to human BDKRB1 (Bradykinin Receptor B1). [provided by Alliance of Genome Resources, Apr 2022]

Bdkrb1 Products(1)

mRNA	Protein	Name
NM_030851.1	NP_110478.1	B1 bradykinin receptor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables bradykinin receptor activity	IDA IDA: Inferred from direct assay	12025968	RGD
enables peptide binding	IPI IPI: Inferred from physical interaction	10422787	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	20411591	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	15253105	RGD
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	16497153	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16497153	RGD
involved in positive regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	12522068	RGD
NOT involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	15319421	RGD
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	15576455	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19561153	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bdkrb1 Protein Structure

7tmA_BK-1

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

B1 bradykinin receptor

B1R	BK-1 receptor
KB1	bradykinin B1 receptor
bradykinin receptor, beta 1	kinin B1 receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01454	BDKRB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01455	Bdkrb1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01456	Bdkrb1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bdkrb1	NCBI	NCBI:623

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