2. Gene
  3. SGPP1 - sphingosine-1-phosphate phosphatase 1 Gene

SGPP1 - sphingosine-1-phosphate phosphatase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SPP-1; SPPase1

Gene ID: 81537 | Gene type: protein coding

About SGPP1

Cytogenetic location: 14q23.2 Genomic coordinates (GRCh38): 14:63,684,216-63,728,065 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 265 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 17.3), lymph node (RPKM 14.6) and 25 other tissues.

Summary

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]

SGPP1 Products(1)

mRNA Protein Name
NM_030791.4 NP_110418.1 sphingosine-1-phosphate phosphatase 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables sphingosine-1-phosphate phosphatase activity IDA
IDA: Inferred from direct assay
16782891 GOA
Biological Process GO Annotation Evidence Reference Source
involved in ER to Golgi ceramide transport IMP
IMP: Inferred from mutant phenotype
16782891 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SGPP1 Protein Structure

PAP2

PAP2: PAP2 superfamily (163 - 278)

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  • 441 a.a.
Protein Preferred Names Protein Names

sphingosine-1-phosphate phosphatase 1

hSPP1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12810 SGPP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SGPP1 VGNC VGNC:104717
Macaca mulatta SGPP1 VGNC VGNC:77261
Canis familiaris SGPP1 VGNC VGNC:46103
Mus musculus SGPP1 MGD MGI:2135760
Bos taurus SGPP1 VGNC VGNC:34548
Rattus norvegicus SGPP1 RGD RGD:727829