TXNDC5 - thioredoxin domain containing 5 Gene

Homo sapiens

Also known as HCC2; ERP46; HCC-2; STRF8; PDIA15; UNQ364; ENDOPDI

Gene ID: 81567 | Gene type: protein coding

About TXNDC5

Cytogenetic location: 6p24.3 Genomic coordinates (GRCh38): 6:7,881,517-7,910,788 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 13 paralogues. Ubiquitous expression in urinary bladder (RPKM 151.7), colon (RPKM 127.4) and 25 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from Apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]

TXNDC5 Products(2)

mRNA	Protein	Name
NM_001145549.4	NP_001139021.1	thioredoxin domain-containing protein 5 isoform 3
NM_030810.5	NP_110437.2	thioredoxin domain-containing protein 5 isoform 1 precursor

TXNDC5 Protein Structure

Thioredoxin

0
100
200
300
400
432 a.a.

Protein Preferred Names

Protein Names

thioredoxin domain-containing protein 5

ER protein 46

Recombinant TXNDC5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71609	TXNDC5 Protein, Human (GST)	Q8NBS9-2 (R33-L324)	≥95%

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 33

DEE33	Epileptic Encephalopathy, Early Infantile, 33
Eiee33	Developmental And Epileptic Encephalopathy, 33
Early Infantile Epileptic Encephalopathy 33	Encephalopathy, Epileptic, Early Infantile, Type 33

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122895	E64FC26		98.10%	Unkown
HY-122895A	(E/Z)-E64FC26		98.09%	Unkown
HY-RS15294	TXNDC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TXNDC5	VGNC	VGNC:107007
Macaca mulatta	TXNDC5	VGNC	VGNC:79304
Mus musculus	TXNDC5	MGD	MGI:2145316
Felis catus	TXNDC5	VGNC	VGNC:102543
Canis familiaris	TXNDC5	VGNC	VGNC:48015
Rattus norvegicus	TXNDC5	RGD	RGD:2323973
Others	TXNDC5	NCBI

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