1. Gene
  2. TXNDC5 - thioredoxin domain containing 5 Gene

TXNDC5 - thioredoxin domain containing 5 Gene

Homo sapiens

Also known as HCC2; ERP46; HCC-2; STRF8; PDIA15; UNQ364; ENDOPDI

Gene ID: 81567 | Gene type: protein coding

About TXNDC5

Cytogenetic location: 6p24.3 Genomic coordinates (GRCh38): 6:7,881,517-7,910,788 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 13 paralogues. Ubiquitous expression in urinary bladder (RPKM 151.7), colon (RPKM 127.4) and 25 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from Apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]

TXNDC5 Products(2)

mRNA Protein Name
NM_001145549.4 NP_001139021.1 thioredoxin domain-containing protein 5 isoform 3
NM_030810.5 NP_110437.2 thioredoxin domain-containing protein 5 isoform 1 precursor

TXNDC5 Protein Structure

Thioredoxin

Thioredoxin: Thioredoxin (68 - 164)

Thioredoxin

Thioredoxin: Thioredoxin (193 - 292)

Thioredoxin

Thioredoxin: Thioredoxin (324 - 425)

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  • 432 a.a.
Protein Preferred Names Protein Names

thioredoxin domain-containing protein 5

ER protein 46

Recombinant TXNDC5 Proteins

Cat. No. Product Name Accession Purity
HY-P71609 TXNDC5 Protein, Human (GST) Q8NBS9-2 (R33-L324) ≥95%

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 33

DEE33

Epileptic Encephalopathy, Early Infantile, 33

Eiee33

Developmental And Epileptic Encephalopathy, 33

Early Infantile Epileptic Encephalopathy 33

Encephalopathy, Epileptic, Early Infantile, Type 33

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus TXNDC5 VGNC VGNC:107007
Macaca mulatta TXNDC5 VGNC VGNC:79304
Mus musculus TXNDC5 MGD MGI:2145316
Felis catus TXNDC5 VGNC VGNC:102543
Canis familiaris TXNDC5 VGNC VGNC:48015
Rattus norvegicus TXNDC5 RGD RGD:2323973
Others TXNDC5 NCBI