COL21A1 - collagen type XXI alpha 1 chain Gene

Homo sapiens

Also known as FP633; COLA1L

Gene ID: 81578 | Gene type: protein coding

About COL21A1

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:56,056,590-56,394,128 (from NCBI)

This gene has 12 transcripts (splice variants), 109 orthologues and 37 paralogues. Broad expression in placenta (RPKM 9.8), heart (RPKM 8.6) and 16 other tissues.

Summary

This gene encodes the alpha chain of type XXI collagen, a member of the FACIT (fibril-associated collagens with interrupted helices) collagen family. Type XXI collagen is localized to tissues containing type I collagen and maintains the integrity of the extracellular matrix. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

COL21A1 Products(5)

mRNA	Protein	Name
NM_001318751.2	NP_001305680.1	collagen alpha-1(XXI) chain isoform a precursor
NM_001318752.2	NP_001305681.1	collagen alpha-1(XXI) chain isoform b precursor
NM_001318753.2	NP_001305682.1	collagen alpha-1(XXI) chain isoform c
NM_001318754.2	NP_001305683.1	collagen alpha-1(XXI) chain isoform d
NM_030820.4	NP_110447.2	collagen alpha-1(XXI) chain isoform a precursor

COL21A1 Protein Structure

VWA

Collagen

0
200
400
600
800
957 a.a.

Protein Preferred Names

Protein Names

collagen alpha-1(XXI) chain

alpha 1 chain-like collagen

Recombinant COL21A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70094	COL21A1 Protein, Human (HEK293, His)	Q96P44-1 (E23-Y957)	≥95%

Related Diseases

Diseases

Alias

Ullrich Congenital Muscular Dystrophy 1

Ullrich Congenital Muscular Dystrophy	Ullrich Disease
Ucmd	Ullrich Scleroatonic Muscular Dystrophy
Scleroatonic Muscular Dystrophy	UCMD1
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22	Lgmdr22
Muscular Dystrophy, Scleroatonic	Late Onset Scleroatonic Familial Myopathy
Congenital Muscular Dystrophy, Ullrich Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02973	COL21A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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