Mapk14 - mitogen activated protein kinase 14 Gene

Rattus norvegicus

Also known as RK; Hog; p38; CRK1; CSBP; Exip; Mxi2; CSPB1; Csbp1; Csbp2; Prkm14; Prkm15; Sapk2A; p38Hog; p38alpha

Gene ID: 81649 | Gene type: protein coding

About Mapk14

Primary_assembly 20: 6,749,670-6,810,589 forward strand.mRatBN7.2:CM026993.1

This gene has 6 transcripts (splice variants), 295 orthologues, 21 paralogues and is associated with 36 phenotypes. Biased expression in Kidney (RPKM 267.1), Adrenal (RPKM 258.5) and 9 other tissues.

Summary

Enables ATP binding activity; MAP kinase activity; and protein C-terminus binding activity. Involved in several processes, including protein autophosphorylation; response to glucose; and stress-activated MAPK cascade. Located in cytosol and nucleus. Used to study diabetic neuropathy and osteoporosis. Biomarker of Alzheimer's disease and anti-basement membrane glomerulonephritis. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Apr 2022]

Mapk14 Products(1)

mRNA	Protein	Name
NM_031020.3	NP_112282.2	mitogen-activated protein kinase 14

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	16879317	RGD
enables MAP kinase activity	IDA IDA: Inferred from direct assay	16407200	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	21607062	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	33409963	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23589286	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	16407200	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	16407200	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	18579738	RGD
involved in stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	16407200	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk14 Protein Structure

STKc_p38alpha

0
100
200
300
360 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 14

Csaids binding protein	MAP kinase 14
MAP kinase 2	MAP kinase Mxi2
MAP kinase p38 alpha	MAPK 14
MAX-interacting protein 2	cytokine suppressive anti-inflammatory drug binding protein
cytokine-supressive anti-inflammatory drug binding protein	mitogen-activated protein kinase 14A
mitogen-activated protein kinase p38 alpha	p38 MAP kinase
p38 mitogen activated protein kinase	p38alpha Exip
reactive kinase	stress-activated protein kinase 2A

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10401	VX-702	Inhibitor	99.54%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148063	DB0614		98.80%	Unkown
HY-18874	p38-α MAPK-IN-1	Inhibitor	99.89%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-RS08108	Mapk14 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08107	MAPK14 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08109	Mapk14 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk14	NCBI	NCBI:1432

Name
Email *

	Sorry, but the email address you supplied was invalid.