2. Gene
  3. Lifr - LIF receptor subunit alpha Gene

Lifr - LIF receptor subunit alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 81680 | Gene type: protein coding

About Lifr

Summary

Enables cytokine binding activity and Leukemia Inhibitory Factor receptor activity. Involved in several processes, including animal organ regeneration; negative regulation of muscle cell apoptotic process; and neuron projection morphogenesis. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Lifr Products(2)

mRNA Protein Name
NM_031048.1 NP_112310.1 leukemia inhibitory factor receptor precursor
NM_031048.1 NP_112310.1 leukemia inhibitory factor receptor precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cytokine binding IMP
IMP: Inferred from mutant phenotype
14638908 RGD
enables leukemia inhibitory factor receptor activity IMP
IMP: Inferred from mutant phenotype
14638908 RGD
Biological Process GO Annotation Evidence Reference Source
involved in animal organ regeneration IMP
IMP: Inferred from mutant phenotype
14638908 RGD
involved in negative regulation of muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
15927854 RGD
involved in neuron projection morphogenesis IDA
IDA: Inferred from direct assay
12871977 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16698589 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukemia inhibitory factor receptor

LIF receptor alpha

LIF-R

leukemia inhibitor factor receptor alpha-chain

leukemia inhibitory factor receptor alpha

Recombinant Lifr Proteins

Cat. No. Product Name Accession Purity
HY-P75907 LIFR Protein, Rat (HEK293, His) G3V7K2 (L44-S829) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120142 EC359 Inducer 99.09% Unkown
HY-169192 BAR-2227 Agonist / Unkown
HY-RS07641 LIFR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lifr NCBI NCBI:3977
Mus musculus Lifr NCBI NCBI:16880