2. Gene
  3. Lifr - LIF receptor alpha Gene

Lifr - LIF receptor alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as LIF; A230075M04Rik

Gene ID: 16880 | Gene type: protein coding

About Lifr

Summary

Predicted to enable several functions, including ciliary neurotrophic factor receptor binding activity; growth factor binding activity; and Leukemia Inhibitory Factor receptor activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and oncostatin-M receptor activity. Acts upstream of or within positive regulation of cell population proliferation. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and immune system. Used to study CAKUT. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Lifr Products(3)

mRNA Protein Name
NM_001113386.1 NP_001106857.1 leukemia inhibitory factor receptor isoform 2 precursor
NM_001358593.1 NP_001345522.1 leukemia inhibitory factor receptor isoform 1 precursor
NM_013584.2 NP_038612.1 leukemia inhibitory factor receptor isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15051883 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
15051883 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukemia inhibitory factor receptor

D-factor/LIF receptor

LIF-R

leukemia inhibitory factor receptor alpha chain

soluble differentiation-stimulating factor receptor

Recombinant Lifr Proteins

Cat. No. Product Name Accession Purity
HY-P77061 LIFR Protein, Mouse (HEK293, His) P42703/NP_038612.1 (L44-S828) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120142 EC359 Inducer 99.09% Unkown
HY-169192 BAR-2227 Agonist / Unkown
HY-RS07641 LIFR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lifr NCBI NCBI:3977
Rattus norvegicus Lifr NCBI NCBI:81680