Mmp14 - matrix metallopeptidase 14 Gene

Rattus norvegicus

Also known as Mt1-mmp

Gene ID: 81707 | Gene type: protein coding

About Mmp14

Primary_assembly 15: 27,887,727-27,899,864 forward strand.mRatBN7.2:CM026988.1

This gene has 3 transcripts (splice variants), 272 orthologues, 23 paralogues and is associated with 34 phenotypes. Biased expression in Uterus (RPKM 594.1), Adrenal (RPKM 38.8) and 9 other tissues.

Summary

Enables Integrin binding activity. Involved in several processes, including gonad development; negative regulation of focal adhesion assembly; and response to odorant. Located in cytoplasm. Used to study ischemia. Biomarker of IgA glomerulonephritis; anti-basement membrane glomerulonephritis; artery disease (multiple); brain ischemia; and congestive heart failure. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14). [provided by Alliance of Genome Resources, Apr 2022]

Mmp14 Products(1)

mRNA	Protein	Name
NM_031056.1	NP_112318.1	matrix metalloproteinase-14 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	19027888	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IEP IEP: Inferred from expression pattern	14766216	RGD
involved in astrocyte cell migration	IEP IEP: Inferred from expression pattern	16265672	RGD
involved in endothelial cell proliferation	IEP IEP: Inferred from expression pattern	14766216	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	22152881	RGD
involved in negative regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	15044209	RGD
involved in ossification	IEP IEP: Inferred from expression pattern	15883642	RGD
involved in ovarian follicle development	IEP IEP: Inferred from expression pattern	15617683	RGD
involved in positive regulation of protein processing	IMP IMP: Inferred from mutant phenotype	14668206	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	15053235	RGD
involved in response to hormone	IDA IDA: Inferred from direct assay	14668206	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	16980344	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	15350851	RGD
involved in response to odorant	IEP IEP: Inferred from expression pattern	23103411	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	11125539	RGD
involved in response to oxidative stress	IEP IEP: Inferred from expression pattern	15642321	RGD
involved in tissue remodeling	IDA IDA: Inferred from direct assay	16740171	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp14 Protein Structure

PG_binding_1

Peptidase_M10

DUF3377

0
100
200
300
400
500
582 a.a.

Protein Preferred Names

Protein Names

matrix metalloproteinase-14

MMP-14	MT-MMP 1
MT1MMP	MTMMP1
matrix metallopeptidase 14 (membrane-inserted)	matrix metalloproteinase 14 membrane-inserted
membrane type 1-matrix metalloproteinase	membrane-type matrix metalloproteinase 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12169	Marimastat	Inhibitor	99.81%	Phase 3

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15827	NSC 405020	Inhibitor	99.67%	Unkown
HY-110397	KP-457	Inhibitor	99.18%	Unkown
HY-107394	UK 356618	Inhibitor	98.91%	Unkown
HY-124373	ND-336	Inhibitor	95.4%	Unkown
HY-107639	UK-370106	Inhibitor	≥99.0%	Unkown
HY-110397G	KP-457 (GMP)	Inhibitor	/	Unkown
HY-114785	BPHA	Inhibitor	/	Unkown
HY-P3120	Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2		96.30%	Unkown
HY-124373A	(R)-ND-336	Inhibitor	/	Unkown
HY-162038	RXP03	Inhibitor	/	Unkown
HY-E70290	N-Acetylgalactosaminyltransferase 1	Agonist	/	Unkown
HY-RS08528	MMP14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08529	Mmp14 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08530	Mmp14 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-35513	3-Aminobenzene-1,2-diol	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mmp14	NCBI	NCBI:4323

Name
Email *

	Sorry, but the email address you supplied was invalid.