MADCAM1 - mucosal vascular addressin cell adhesion molecule 1 Gene

Homo sapiens

Also known as MACAM1

Gene ID: 8174 | Gene type: protein coding

About MADCAM1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:496,486-505,343 (from NCBI)

This gene has 5 transcripts (splice variants) and 96 orthologues. Biased expression in appendix (RPKM 6.2), spleen (RPKM 4.9) and 6 other tissues.

Summary

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 Integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

MADCAM1 Products(2)

mRNA	Protein	Name
NM_130760.3	NP_570116.2	mucosal addressin cell adhesion molecule 1 isoform a precursor
NM_130762.3	NP_570118.1	mucosal addressin cell adhesion molecule 1 isoform b precursor

MADCAM1 Protein Structure

Adhes-Ig_like

0
100
200
300
382 a.a.

Protein Preferred Names

Protein Names

mucosal addressin cell adhesion molecule 1

MAdCAM-1

Recombinant MADCAM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71818	MAdCAM1 Protein, Human (P.pastoris, His-Myc)	Q13477 (19Q-317Q)	≥95%

Related Diseases

Diseases

Alias

Colon Kaposi Sarcoma

Colonic Kaposi'S Sarcoma

Ileitis

Crohn'S Ileitis

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Colitis

Cholangitis

Acute Cholangiolitis	Ascending Cholangitis
Cholangiolitis	Cholangitis Nos
Chronic Cholangiolitis	Hepatic Duct Inflammation
Acute Cholangitis	Bile Duct Inflammation

Type 1 Diabetes Mellitus 21

Diabetes Mellitus, Insulin-Dependent, 21	Iddm21
T1D21	Insulin-Dependent Diabetes Mellitus 21

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

Progressive Multifocal Leukoencephalopathy

Pml	Leukoencephalopathy, Progressive Multifocal
Progressive Multifocal Leukoencephalitis	Leukoencephalopathy Progressive Multifocal
Pml - [Progressive Multifocal Leukoencephalopathy]

Listeria Meningitis

Meningitis, Listeria

Acquired Immunodeficiency Syndrome

Acquired Immune Deficiency Syndrome	AIDS
Acquired Immune Deficiency	Acquired Immunodeficiency
Acquired Immunodeficiency Due To Protein Loss

Ascending Cholangitis

Sclerosing Cholangitis

Fibrosing Cholangitis	Cholangitis, Sclerosing
Primary Sclerosing Cholangitis

Autoimmune Disease Of Gastrointestinal Tract

Gastroduodenal Crohn'S Disease

Upper Gi Crohn'S Disease

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159179	α4 integrin receptor antagonist 3	Inhibitor	/	Unkown
HY-RS07952	MADCAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MADCAM1	RGD	RGD:3029
Canis familiaris	MADCAM1	VGNC	VGNC:42916
Felis catus	MADCAM1	VGNC	VGNC:68127
Mus musculus	MADCAM1	MGD	MGI:103579
Bos taurus	MADCAM1	VGNC	VGNC:31133
Others	MADCAM1	NCBI

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