Rnpep - arginyl aminopeptidase Gene

Rattus norvegicus

Gene ID: 81761 | Gene type: protein coding

About Rnpep

Primary_assembly 13: 46,699,463-46,717,998 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 156 orthologues, 10 paralogues and is associated with 6 phenotypes. Biased expression in Kidney (RPKM 14.6), Testes (RPKM 139.5) and 9 other tissues.

Summary

Enables metalloaminopeptidase activity; peptide binding activity; and transition metal ion binding activity. Involved in several processes, including aging; negative regulation of blood pressure; and retina development in camera-type eye. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and secretory granule. Used to study hypertension. Biomarker of hypertension. Orthologous to human RNPEP (arginyl Aminopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Rnpep Products(1)

mRNA	Protein	Name
NM_031097.2	NP_112359.2	aminopeptidase B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aminopeptidase activity	IDA IDA: Inferred from direct assay	8940051	RGD
enables cobalt ion binding	IDA IDA: Inferred from direct assay	17142967	RGD
enables copper ion binding	IDA IDA: Inferred from direct assay	17142967	RGD
enables metalloaminopeptidase activity	IDA IDA: Inferred from direct assay	17142967	RGD
enables peptide binding	IDA IDA: Inferred from direct assay	16537183	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	17142967	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	3001599	RGD
involved in protein processing	IDA IDA: Inferred from direct assay	16537183	RGD
involved in retina development in camera-type eye	IEP IEP: Inferred from expression pattern	15500823	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	9405297	RGD
located in extracellular region	IDA IDA: Inferred from direct assay	9405297	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	16619500	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	9405297	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	15539558	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rnpep Protein Structure

M1_LTA4H

Leuk-A4-hydro_C

0
100
200
300
400
500
600
650 a.a.

Protein Preferred Names

Protein Names

aminopeptidase B

AP-B	arginine aminopeptidase
cytosol aminopeptidase IV

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12104	RNPEP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12105	Rnpep Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12106	Rnpep Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rnpep	NCBI	NCBI:6051

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