2. Gene
  3. KDM5D - lysine demethylase 5D Gene

KDM5D - lysine demethylase 5D Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HY; HYA; SMCY; JARID1D

Gene ID: 8284 | Gene type: protein coding

About KDM5D

Cytogenetic location: Yq11.223 Genomic coordinates (GRCh38): Y:19,703,865-19,744,726 (from NCBI)

This gene has 10 transcripts (splice variants), 110 orthologues, 10 paralogues and is associated with 1 phenotype. Broad expression in small intestine (RPKM 5.6), prostate (RPKM 3.5) and 20 other tissues.

Summary

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

KDM5D Products(3)

mRNA Protein Name
NM_001146705.2 NP_001140177.1 lysine-specific demethylase 5D isoform 1
NM_001146706.2 NP_001140178.1 lysine-specific demethylase 5D isoform 3
NM_004653.5 NP_004644.2 lysine-specific demethylase 5D isoform 2

KDM5D Protein Structure

JmjN

JmjN: jmjN domain (15 - 48)

ARID

ARID: ARID/BRIGHT DNA binding domain (77 - 165)

PHD

PHD: PHD-finger (316 - 362)

JmjC

JmjC: JmjC domain, hydroxylase (491 - 607)

zf-C5HC2

zf-C5HC2: C5HC2 zinc finger (697 - 750)

PLU-1

PLU-1: PLU-1-like protein (761 - 1087)

PHD

PHD: PHD-finger (1174 - 1236)

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  • 1539 a.a.
Protein Preferred Names Protein Names

lysine-specific demethylase 5D

H-Y

Related Diseases

Diseases Alias
Spermatogenic Failure, Y-Linked, 2

SPGFY2

Spermatogenic Failure, Nonobstructive, Y-Linked

Y-Linked Spermatogenic Failure 2

Azoospermia, Nonobstructive, Y-Linked

Oligozoospermia, Nonobstructive, Y-Linked

Oligospermia, Nonobstructive, Y-Linked

Spermatogenic Arrest, Y-Linked

Nonobstructive Y-Linked Spermatogenic Failure

Spermatogenic Failure Y-Linked 2

Azoospermia Non-Obstructive Y-Linked

Non-Obstructive Azoospermia And Infertility

Oligospermia Non-Obstructive Y-Linked

Oligozoospermia Non-Obstructive Y-Linked

Spermatogenic Arrest Y-Linked

Spermatogenic Failure Nonobstructive Y-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-102047B KDOAM-25 citrate Inhibitor 98.11% Unkown
HY-102047 KDOAM-25 Inhibitor / Unkown
HY-102047A KDOAM-25 trihydrochloride Inhibitor / Unkown
HY-RS07221 KDM5D Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KDM5D MGD MGI:99780
Macaca mulatta KDM5D VGNC VGNC:101430
Rattus norvegicus KDM5D RGD RGD:2314436