1. Gene
  2. KLRC4 - killer cell lectin like receptor C4 Gene

KLRC4 - killer cell lectin like receptor C4 Gene

Homo sapiens

Also known as NKG2F; NKG2-F

Gene ID: 8302 | Gene type: protein coding

About KLRC4

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,407,384-10,409,757 (from NCBI)

This gene has 1 transcript (splice variant), 368 orthologues, 23 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 6.6), lymph node (RPKM 3.0) and 17 other tissues.

Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010]

KLRC4 Products(1)

mRNA Protein Name
NM_013431.2 NP_038459.1 NKG2-F type II integral membrane protein
Protein Preferred Names Protein Names

NKG2-F type II integral membrane protein

NK cell receptor F

Related Diseases

Diseases Alias
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease

Immunodeficiency 31a

Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Stat1 Deficiency

IMD31A

Immunodeficiency 31a, Mycobacteriosis, Autosomal Dominant

Stat1 Deficiency, Autosomal Dominant

Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Signal Transducer And Activator Of Transcription 1 Deficiency

Msmd Due To Partial Signal Transducer And Activator Of Transcription 1 Deficiency

Msmd Due To Partial Stat1 Deficiency

Autosomal Dominant Immunodeficiency 31a, Mycobacteriosis

Immunodeficiency, Type 31a, Mycobacteriosis, Autosomal Dominant

Immunodeficiency 31c

IMD31C

Candidiasis, Familial, 7

Candf7

Candidiasis, Familial Chronic Mucocutaneous, Autosomal Dominant

Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome

Autoimmune Enteropathy And Endocrinopathy - Susceptibility To Chronic Infections Syndrome

Immunodeficiency 31c, Chronic Mucocutaneous Candidiasis, Autosomal Dominant

Autosomal Dominant Chronic Mucocutaneous Familial Candidiasis

Autosomal Dominant Immunodeficiency 31c

Familial Candidiasis 7

Chronic Mucocutaneous Candidiasis 7

Immunodeficiency 31c, Autosomal Dominant

Immunodeficiency, Type 31c, Autosomal Dominant

Aphthous Stomatitis

Oral Ulcer

Canker Sore

Aphtha

Aphthous Ulceration

Oral Aphthae

Oral Aphthous Ulcer

Canker Sores

Stomatitis, Aphthous

Minor Oral Aphthous Ulceration

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma