FZD1 - frizzled class receptor 1 Gene

Homo sapiens

Gene ID: 8321 | Gene type: protein coding

About FZD1

Cytogenetic location: 7q21.13 Genomic coordinates (GRCh38): 7:91,264,433-91,271,326 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and 15 paralogues.

Summary

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]

FZD1 Products(1)

mRNA	Protein	Name
NM_003505.2	NP_003496.1	frizzled-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	19388021	GOA
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	10557084	GOA
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	10557084	GOA
enables frizzled binding	IPI IPI: Inferred from physical interaction	19188438	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19277043	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	14739301	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autocrine signaling	IDA IDA: Inferred from direct assay	10557084	GOA
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	10557084	GOA
involved in canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	11433302	GOA
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20039315	GOA
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	10557084	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10557084	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18929644	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20039315	GOA
involved in regulation of mesenchymal stem cell differentiation	IMP IMP: Inferred from mutant phenotype	20039315	GOA
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	19421142	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	19643732	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD1 Protein Structure

Frizzled

0
100
200
300
400
500
600
647 a.a.

Protein Preferred Names

Protein Names

frizzled-1

Wnt receptor

Related Diseases

Diseases

Alias

Omodysplasia

Omodysplasia Type 1

Omodysplasia 2

Fallopian Tube Serous Adenocarcinoma

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9974	Vantictumab	Inhibitor	99.40%	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05176	FZD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FZD1	MGD	MGI:1196625
Felis catus	FZD1	VGNC	VGNC:62402
Rattus norvegicus	FZD1	RGD	RGD:61916
Canis familiaris	FZD1	VGNC	VGNC:41028
Bos taurus	FZD1	VGNC	VGNC:29165
Others	FZD1	NCBI

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